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EC number: 214-881-6 | CAS number: 1205-17-0
Table 1: Results at pH 4 (50.0 ± 0.5 °C)
% of Mean Initial Concentration
Less than 10 % hydrolysis after 5 days at 50 °C, equivalent to a half-life greater than 1 year at 25 °C.
Table 2: Results at pH 7 (50.0 ± 0.5 °C)
Table 3: Results at pH 9 (50.0 ± 0.5 °C)
A study was conducted to investigate the potential hydrolysis as a function of pH of the test material in accordance with the standardised guidelines OECD 111 and EU Method C.7 under GLP conditions.
The potential of the test material to undergo hydrolysis was investigated at buffer solutions prepared at pH 4, 7 and 9 at 50 °C in the dark for a period of five days. The buffer solutions were subjected to ultrasonication and degassing with nitrogen to minimise dissolved oxygen content.
Changes in the concentration of test material were monitored after 24 and 120 h using HPLC analysis with UV detection at 288 nm.
Less than 10 % hydrolysis was seen after 120 hours at 50 °C for all three buffers.
Under the conditions of this study, the test material was estimated to have a half-life >1 year at pH 4, 7 and 9 at 25 °C.
The test material was estimated to have a half-life >1 year at pH 4, 7 and 9 at 25 °C.
A study was conducted to investigate the potential hydrolysis as a function of pH of the test material in accordance with the standardised guidelines OECD 111 and EU Method C.7 under GLP conditions. The study was assigned a reliability score of 1 in accordance with the criteria for assessing data quality set forth by Klimisch et al. (1997).
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