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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Animal studies show that 1,1,1,2,3,3,3-heptafluoropropane (HFC 227ea) has low acute inhalational toxicity.

Key value for chemical safety assessment

Acute toxicity: via inhalation route

Endpoint conclusion
Dose descriptor:
5 483 776 mg/m³ air

Additional information

In accordance with section 2 of REACH Annex XI, an acute oral and dermal toxicity study do not need to be conducted as the substance is a gas.

Available acute inhalation toxicity studies with 1,1,1,2,3,3,3 -heptafluoropropane indicate that the acute inhalation toxicity study is low.

In the key study (WIL Research Laboratories, 1992) no mortality was observed and a 4 h-LC50 > 788696 ppm (5483776 mg/m3) was established. At this concentration, only transient signs of anaesthesia during the exposure period and a decreased body weight and body weight gain at the end of the 14 -day observation period were observed.

Justification for classification or non-classification

Based on 4 h LC50 of > 788696 ppm (5,483,776 mg/m3) in rats in a reliable OECD guideline study, 1,1,1,2,3,3,3 -heptafluoropropane does not have to be classified for acute toxicity in accordance with EU Directive 67/548/EEC and EU Classification, Labeling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.