Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Specific investigations: other studies

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

The results of a cardiac sensitisation study in the dog showed the substance to be capable of sensitising the heart to the effects of adrenalin at concentrations from 9% onwards. 

Additional information

An available acute cardiac sensitisation study with dogs (WIL Research Laboratories, Inc., 1993b) indicated that 1,1,1,2,3,3,3-heptafluoropropane causes a sensitisation (specifically the occurrence of one or more premature ventricular contractions) of a canine heart to the effects of adrenaline after exposure to 9%, 10.5% and 14% 1,1,1,2,3,3,3 -heptafluoropropane. The severity of the cardiac responses increased dose-dependently. There were no treatment-related clinical findings.