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Description of key information

The results of a cardiac sensitisation study in the dog showed the substance to be capable of sensitising the heart to the effects of adrenalin at concentrations from 9% onwards. 

Additional information

An available acute cardiac sensitisation study with dogs (WIL Research Laboratories, Inc., 1993b) indicated that 1,1,1,2,3,3,3-heptafluoropropane causes a sensitisation (specifically the occurrence of one or more premature ventricular contractions) of a canine heart to the effects of adrenaline after exposure to 9%, 10.5% and 14% 1,1,1,2,3,3,3 -heptafluoropropane. The severity of the cardiac responses increased dose-dependently. There were no treatment-related clinical findings.