Sodium tris(1,2-naphthoquinone 1-oximato-O,O')ferrate(1-)

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Data is from Handbook.

Data source

Reference

Reference 1

Reference Type:

secondary source

Title:

Reports of the Scientific Committee on Cosmetology (seventh series)

Author:

Commission of the European Communities

Year:

1988

Bibliographic source:

Directorate-General Environment, Consumer Protection and Nuclear Safety- Commission of the European Communities- Brussels Luxembourg, 1988.

Reference 2

Reference Type:

review article or handbook

Title:

Acute Oral Toxicity of Sodium tris(1,2-naphthoquinone 1-oximato-O,O')ferrate(1-) (CAS no: 16143-80-9) in rat.

Author:

Gisbert Otterstatter

Year:

1999

Bibliographic source:

Coloring of Food, Drugs, and Cosmetics, 1999.

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: as below

Principles of method if other than guideline:

Acute Oral Toxicity of Sodium tris(1,2-naphthoquinone 1-oximato-O,O')ferrate(1-) (CAS no: 16143-80-9) in rat.

GLP compliance:

not specified

Test type:

other: No data

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Sodium tris(1,2-naphthoquinone 1-oximato-O,O')ferrate(1-)

Cas Number:

16143-80-9

Molecular formula:

C30H18Fe-N3O6.Na

IUPAC Name:

Sodium tris(1,2-naphthoquinone 1-oximato-O,O')ferrate(1-)

Details on test material:

- Name of test material (as cited in study report): C.I. Pigment Green 8 (Sodium tris(1,2-naphthoquinone 1-oximato-O,O')ferrate(1-))
- Molecular formula (if other than submission substance): C30H18FeN3O6.Na
- Molecular weight (if other than submission substance): 595.3222 g/mol
- Substance type: Organic
- Physical state: Solid

Specific details on test material used for the study:

- Name of test material : Sodium tris (1, 2-naphthoquinone 1-oximato-O, O’) ferrate (1- )
- Molecular formula : C30H18FeN3O6.Na
- Molecular weight : 595.3222 g/mol
- Smiles notation : [Na+].[Fe+2].[O-]\N=C\1/C(=O)C=Cc2ccccc12.[O-]\N=C\3/C(=O)C=Cc4ccccc34.[O-]\N=C\5/C(=O)C=Cc6ccccc56
- InChl : HWLCXJRHGUPXJZ-ZHJLFMMCSA-K
- Substance type: Organic
- Physical state: Solid

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

not specified

Administration / exposure

Route of administration:

oral: unspecified

Vehicle:

not specified

Details on oral exposure:

not specified

Doses:

10000 mg/kg

No. of animals per sex per dose:

not specified

Control animals:

not specified

Details on study design:

not specified

Statistics:

not specified

Results and discussion

Preliminary study:

not specified

Effect levels

Sex:

not specified

Dose descriptor:

LD50

Effect level:

> 10 000 mg/kg bw

Based on:

test mat.

Remarks on result:

other: No mortality observed

Mortality:

No mortality was observed in treated rat at 10000 mg/kg

Clinical signs:

other: not specified

Gross pathology:

not specified

Other findings:

not specified

Applicant's summary and conclusion

Interpretation of results:

other: Not classified

Conclusions:

The acute oral LD50 was considered to be >10000 mg/kg bw, when rats were treated with Sodium tris(1,2-naphthoquinone 1-oximato-O,O')ferrate(1-) (CAS no: 16143-80-9) via oral route.

Executive summary:

Acute oral toxicity study was conducted by using Sodium tris(1,2-naphthoquinone 1-oximato-O,O')ferrate(1-) (CAS no: 16143-80-9) in rats at the concentration of 10000 mg/kg bw. No mortality was observed in treated rats. Therefore, LD50 was considered to be >10000 mg/kg bw, when rats were treated withSodium tris(1,2-naphthoquinone 1-oximato-O,O')ferrate(1-) via oral route.