Sodium tris(1,2-naphthoquinone 1-oximato-O,O')ferrate(1-)

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

secondary literature

Justification for type of information:

Data is from HPVIS database.

Data source

Reference

Reference Type:

secondary source

Title:

Acute dermal toxicity for CAS 101-02-0

Author:

U.S Environmental Protection agency

Year:

2018

Bibliographic source:

High Production Volume Information System (HPVIS)

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

Version / remarks:

The method employed in the testing, evaluation, and the scoring of the results was similar to the methods described in Section 1500.40 of the U.S. Federal Hazardous Substances Act Regulations, 16 CFF, pg. 123. [Comparable to OECD Test Guideline 402]

Principles of method if other than guideline:

Acute dermal toxicity of Phosphorous acid, triphenyl ester (CAS no.: 101-02-0) in rabbit

GLP compliance:

not specified

Test type:

other: not specified

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Triphenyl phosphite

EC Number:

202-908-4

EC Name:

Triphenyl phosphite

Cas Number:

101-02-0

Molecular formula:

C18H15O3P

IUPAC Name:

Triphenyl phosphite

Specific details on test material used for the study:

- Name of test material (as cited in study report): Phosphorous acid, triphenyl ester
- Molecular formula (if other than submission substance): C18-H15-O3-P
- Molecular weight (if other than submission substance): 310.2875
- Substance type: Organic
- Physical state: liquid
- Purity: > 97%

Test animals

Species:

rabbit

Strain:

New Zealand White

Sex:

male/female

Details on test animals or test system and environmental conditions:

- Weight at study initiation: between 2.0 and 3.0 kg

Administration / exposure

Type of coverage:

occlusive

Vehicle:

unchanged (no vehicle)

Details on dermal exposure:

The sample was dosed as supplied (described as a colorless to straw-colored liquid).

Duration of exposure:

24 hours

Doses:

2 and 5 g/kg

No. of animals per sex per dose:

3/sex

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 21-day

Statistics:

not specified

Results and discussion

Preliminary study:

not specified

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

>= 2 000 - <= 5 000 mg/kg bw

Based on:

test mat.

Mortality:

At a dose of 5 g/kg, all three males and females died. At 2 g/kg, no animals died.

Clinical signs:

other: At a dose of 5 g/kg: After 5-6 hours, the animals appeared cold, and lethargic. They became semi-comatose after 8 hours and deaths occurred over approximately 2-3 days after dosing. At dose 2mg/kg: there were no remarkable findings, except for substantial

Gross pathology:

At dose 2mg/kg: Gross pathological examination revealed no remarkable findings.

Other findings:

not specified

Applicant's summary and conclusion

Interpretation of results:

other: Not classified

Conclusions:

Acute dermal LD50 value of the substance Phosphorous acid, triphenyl ester was determined to be in between the range of > 2000 - < 5000 mg/kg for New Zealand white rabbits.

Executive summary:

Acute dermal toxicity of the substance Phosphorous acid, triphenyl ester (CAS 101-02-0) was determined in New Zealand white rabbits as per the methods described in Section 1500.40 of the U.S. Federal Hazardous Substances Act Regulations, 16 CFF, pg. 123. [Comparable to OECD Test Guideline 402].  The sample was applied as supplied to the back of each animal at dose of 5.0 g/kg body weight. These treated areas were covered with large gauze patches and an impervious material was wrapped around the trunk of each animal. The dressings were removed after 24 hours and any excess material was removed. The animals were observed for a 21-day period for signs of toxicity and mortality. At a dose of 5 g/kg, all three males and females died. After 5-6 hours, the animals appeared cold, and lethargic. They became semi-comatose after 8 hours and deaths occurred over approximately 2-3 days after dosing. At 2 g/kg, no animals died and there were no remarkable findings, except for substantial skin irritation lasting over several days. Gross pathological examination revealed no remarkable findings. Thus, acute dermal LD50 value of the substance Phosphorous acid, triphenyl ester was determined to be in between the range of > 2000 - < 5000 mg/kg for New Zealand white rabbits.