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EC number: 630-473-4 | CAS number: 14595-54-1
Table 4.2/1: Results of the DSC-measurements
Onset of Effect (°C)
Range of effect (°C)
Air pressure (hpa)
21 to 22 (exo)
-39 to -38 (exo)
-50 to -25 (endo)
-10 to 10 (endo)
15 to 35 (endo)
230 to 380 (endo)
230 to 370 (endo)
During the cooling to a temperature of -100 °C two sharp exothermic effects could be observed in a temperature range from -39 to 22 °C, which can be assigned to the freezing of the test item. As there are two exothermic signals, the test item has a freezing range from -39 to 20 °C by evaluating minimum and maximum onset temperatures of the effects. During the subsequent heating phase three distinct endothermic effects were observed in the temperature range from -50 to 35 °C, which can be assigned to the melting of the test item. As there are three endothermic signals, the test item has a melting range from -38 to 23 °C by evaluating minimum and maximum onset temperatures of the effects.
The observation of more than one melting point might be caused by the existence of different isomers of the test item. Here, for example, the keto-enol automatism can lead to three different stable isomers of the test substance. Another explanation might be the existence of ring conformational isomerism which can lead to several stable conformers.
The freezing and melting points of the test substance were determined under GLP according to EU Method A.1 and OECD 102, by differential scanning calorimetry (DSC). Two main runs were performed, and the average of the onset temperatures was retained.
The test item undergoes freezing in two steps at +20°C and -39°C, and melting in three steps from -38 to 23 °C, at atmospheric pressure (1009 hPa) under nitrogen. The phenomenon may be due to isomerism (or crystal rearrangement) of the substance.
2-step Freezing in the range from +20°C to -39°C.3-step Melting in the range from -38°C to 23°C (both results at atmospheric pressure 1009 hPa under nitrogen)
A fully reliable experimental study, conducted according to a recognized OECD/EC method and under GLP, is available. It is considered as a key study. As both transitions occur in multi-step, the results are expressed as a melting/freezing range, and cannot be retained as (single) key value.
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