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Diss Factsheets
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EC number: 630-473-4 | CAS number: 14595-54-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
One experimental study and two reliable QSAR results are available to assess the aquatic toxicity of the registered substance.
To assess the short-term toxicity to aquatic invertebrates, one experimental study and one QSAR result are available on the registered substance.
The experimental study (NOACK, 2018) was assessed as the key study and was performed on the registered substance according to OECD Guideline 202 with GLP statement using a passive dosing system. The test substance was exposed to Daphnia magna at five concentrations (at and below maximum achievable water solubility) and a control, under static conditions for 48 hours. According to the results of this study, the 48h-EC50 was determined at 0.682 mg/L (95% CL: 0.627 - 0.753 mg/L), based on initial measured concentrations of the test substance.
The QSAR prediction (KREATiS, 2017; Model:iSafeRat® holistic HA-QSAR v1.7), assessed as a supporting data, was performed on the registered substance. The immobility of the daphnids was determined using a validated QSAR for the Mode of Action in question, (MOA 1, non-polar narcosis), using a training set of 58 chemicals derived from 48 -hour tests on daphnids, for which the concentrations of the test substance had been determined by chemical analyses over the test period. The 48h-EC50 value on the registered substance based on mobility was determined at 1.1 mg/L (95% CL: 1.1-1.2 mg/L).This QSAR result supports the experimental key study performed on the same substance with an EC50 value in the same order of magnitude, considering the biological and experimental variabilities (factor <2) . Therefore, this QSAR is considered relevant and sufficient to assess, alone, the toxicity of the registered substance to aquatic algae, without the use of an experimental study.
To assess the toxicity of the registered substance to aquatic algae, the QSAR model presented above (iSafeRat holistic approach v1.7) was used. The growth inhibition of algae was determined using a validated QSAR for the Mode of Action in question, (MOA 1, non-polar narcosis), using a training set of 40 chemicals derived from 72 -hour ErC50 tests on algae, for which the concentrations of the test substance had been determined by chemical analyses over the test period. The 72h-ErC50 value on the registered substance based on growth rate was determined at 0.98 mg/L (95% CL: 0.92 - 1.0 mg/L). An in vivo algae study is not considered necessary as this QSAR is considered sufficient to cover this endpoint.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.