Cyclopentene

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Acceptable for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1973

Materials and methods

Principles of method if other than guideline:

BASF test:
1 ml of the test substance was applied to the skin of two rabbits. Readings were performed using a BASF scheme which is convertable into the Draize system (s. Details on study design)

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Cyclohexene

EC Number:

203-807-8

EC Name:

Cyclohexene

Cas Number:

110-83-8

Molecular formula:

C6H10

IUPAC Name:

cyclohexene

Test animals

Species:

rabbit

Test system

Type of coverage:

occlusive

Amount / concentration applied:

TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 1 ml

Duration of treatment / exposure:

20 hours

Observation period:

8 days

Number of animals:

2

Details on study design:

TEST SITE
- Area of exposure: 2.5 X 2.5 cm

REMOVAL OF TEST SUBSTANCE
- Washing (if done): no washing done


SCORING SYSTEM:
BASF scheme
Erythema:
(+) corresponds to Draize score 1
R+ corresponds to Draize score 2
R++ corresponds to Draize score 3
R+++ corresponds to Draize score 4
Edema
Ö(+) corresponds to Draize score 1
Ö+ vorresponds to Draize score 2
Ö++ corresponds to Draize score 3
Sack Ö+++ corresponds to Draize score 4
Sch+ slight scales
Sch++ rhagade-like scales

Readings were performed 24 hours, 48 hours 5, 7 and 8 days after the application of the test substance.

Results and discussion

In vivo

Results

Results 1

Irritation parameter:

erythema score

Basis:

mean

Time point:

other: 24 and 48 hours

Score:

1.75

Max. score:

4

Reversibility:

not fully reversible within: 8 days (only animal 1)

Results 2

Irritation parameter:

edema score

Basis:

mean

Time point:

other: 24 and 48 hours (5 days)

Score:

2

Max. score:

4

Reversibility:

not fully reversible within: 8 days

Remarks on result:

other: for animal 1 the 5 day score was considered instead of the 48 hours score; slight scaling was observed after 7 and 8 days

Any other information on results incl. tables

	Animal 1		Animal 2		Mean
	Erythema	Ed.	Erythema	Edema	Ery.	Ed.
24 hours	1	2	2	2	1.5	2
48 hours	2	unknown	2	2	2	-
5 days	2	2	2	2	2	2
7 days	2	slight scaling	0	slight scaling	1	-
8 days	1	slight scaling	0	slight scaling	0.5	-
Mean 24 and 48 hours	1.5	-	2	2