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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Comparable to guideline study with acceptable restrictions; no necropsy performed; no data about doses used; no mortality data available.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Range finding toxicity data: List VI.
Author:
Smyth H.F. et al.:
Year:
1962
Bibliographic source:
J. Amer. Ind. Hyg. Assoc. J. 23: 95
Reference Type:
publication
Title:
Range finding toxicity data: List VII.
Author:
Smyth H.F. et al.
Year:
1969
Bibliographic source:
J. Amer. Ind. Hyg. Assoc. J. 30: 470

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Method is described in the publication of Smyth et al (cf. Reference)
Gastric intubation of groups of 5 non-fasted male Carworth-Wistar rats (age: 4-5 weeks; bw: 90-120 g). The dosages were arranged in a logarithmic series differing by a factor of two. 14 days post-exposure observation period. No further details.
GLP compliance:
not specified
Test type:
other: Smyth and Carpenter (see reference)

Test material

Constituent 1
Chemical structure
Reference substance name:
Cyclopentene
EC Number:
205-532-9
EC Name:
Cyclopentene
Cas Number:
142-29-0
Molecular formula:
C5H8
IUPAC Name:
cyclopentene
Details on test material:
no further data available

Test animals

Species:
rat
Strain:
Wistar
Sex:
male

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Doses:
1656.0 mg/kg bw (Original value 2.14 ml/kg (density cyclopentene 0.774 g/ml);
As no information about the number of administered dose levels is given, the total amount of animals could not be determined.
No. of animals per sex per dose:
5
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
1 656 mg/kg bw

Applicant's summary and conclusion