Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 244-966-3 | CAS number: 22412-97-1
Effects on the lymph nodes:
The right auricular node was enlarged in 1/5 mice in the highest dose group. As this was a single case, it is not considered to be a sensitivity reaction. No macroscopic abnormalitites were observed in the surrounding area.
Table 1: Individual values for radioactivity measurements (disintegrations per minute) and mean stimulation indices
Concentration (% w/w)
Stimulation index (mean± SEM)
Mean ± SEM
488 ± 43
1.0 ± 0.1
571 ± 62
1.2 ± 0.2
951 ± 134
1.0 ± 0.3
1013 ± 146
1.1 ± 0.1
DPM = disintegrations per minute
SEM = standard error of the mean
Skin irritation effects:
Slight erythema was observed at the test site on both ears in 5/5 mice exposed to 100% test substance. This was not considered to have affected the activity of the lymph nodes.
There was no mortality. No clinical signs were observed during the study period and there were no effects on body weight.
A mouse Local Lymph Node Assay (LLNA) with the analogue decyl oleate (Cas# 3687-46-5) showed a mean SI for the control, 25, 50 and 100% groups of 1.0, 1.2, 2.0 and 2.1, respectively. Hence, the conclusion was that this fatty alkyl ester was not sensitizing. A traditional guinea pig test with intradermal exposure confirmed the lack of significant sensitization.
The results of the cited studies showed no potency of sensitizing properties for fatty alkyl esters.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again