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Diss Factsheets
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EC number: 244-966-3 | CAS number: 22412-97-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given. The analytical purity of the substance in the test product was not reported. Instead, it was based upon the estimated ranges for the product derived from the production recipe.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OPP 81-4 (Acute Eye Irritation)
- Deviations:
- not specified
- GLP compliance:
- no
Test material
- Reference substance name:
- Tetradecyl laurate
- EC Number:
- 244-966-3
- EC Name:
- Tetradecyl laurate
- Cas Number:
- 22412-97-1
- Molecular formula:
- C26H52O2
- IUPAC Name:
- tetradecyl laurate
- Reference substance name:
- Tetradecyl myristate
- EC Number:
- 221-787-9
- EC Name:
- Tetradecyl myristate
- Cas Number:
- 3234-85-3
- Molecular formula:
- C28H56O2
- IUPAC Name:
- tetradecyl myristate
- Reference substance name:
- 112-72-1
- Cas Number:
- 112-72-1
- IUPAC Name:
- 112-72-1
- Details on test material:
- - Name of test material (as cited in study report): Ceraphyl 424
- Analytical purity: mixture of tetradecyl myristate, tetradecyl laurate and tetradecanol (approx. 60-30-10 %w/w)
- Received: November 13, 1975
Constituent 1
Constituent 2
Constituent 3
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- A group of 6 albino rabbits was used in this study to determine the toxicity of the substance submitted, to eye musoca.
Test system
- Vehicle:
- other: corn oil
- Controls:
- not required
- Amount / concentration applied:
- Material was tested as a freshly prepared 15% solution in corn oil. One tenth of a milliliter of the product under test was instilled into the conjunctiva! sacs of the test animals. All the treated eyes remained unwashed.
- Observation period (in vivo):
- The evaluations were performed at one, twenty-four, etc. hours until seven days had elapsed. A 2% instillation of fluorescein was made on each animal at least once, during the course of the experimental period.
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- The test material was allowed to fall on the everted lower lid of each rabbit, the upper and lower lids were then gently held together for one second before releasing to prevent loss of material. Macroscopic readings were facilitated with microscopic readings (slit lamp examinations). A preparation eliciting corneal and iris lesions, which had not cleared by the seventh day were considered to be a severe eye irritant. The cornea was scored on the basis of the density of the opacity and the total area involved. The iris was scored on the intensity or degree of inflammation exhibited; and the palpebral and bulbar mucosae were scored on the extent of chemosis, hyperemia and discharge.
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- other: total
- Time point:
- other: up to 7 days
- Score:
- 34
- Max. score:
- 110
- Reversibility:
- fully reversible
Applicant's summary and conclusion
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: US CPSC / US FDA
- Conclusions:
- Does not require labeling for eye irritancy under the Federal Hazardous Substances Act.
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