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EC number: 201-757-1 | CAS number: 87-61-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
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- Endpoint summary
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- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
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- Long-term toxicity to aquatic invertebrates
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- Toxicological Summary
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- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From: 12.1.1982 To: 2.2.1982
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with accepatable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report Date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- No analytical purity reported. No GLP. Only 2 dosis tested.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Details on test material:
- - Name of test material (as cited in study report): 1,2,3-trichlorobenzene solidified melted
- Physical state: solid
- Analytical purity: not reported
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Source: Sparte, OC, Germany
- Age at study initiation: 9-14 weeks old
- Weight at study initiation: 182 (males), 177 (females)
- Fasting period before study: from 16 hours before the application to 4 hours after the application
- Housing: Makrolon cages type III
- Diet (e.g. ad libitum): ad libitum (except during the fasting period)
- Water (e.g. ad libitum): ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 1.5 ° C
- Humidity (%): 60 ± 5%
- Photoperiod (hrs dark / hrs light): 12 hrs dark / 12 hrs light (7 a.m-7 p.m)
IN-LIFE DATES: From: 12.1.1982 To: 2.2.1982
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: Lutrol
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 20 mL/kg bw
- Doses:
- 3100 and 5000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- other: not applicable
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: At the day of the treatment the animals were controlled several times. During the 14-day observation period they were monitored twice per day ( once per day over weekends and holidays). The body weights were recorded at the day of the treatment, after 1 week and the end of the observation period.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, gross pathology
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Remarks on result:
- other: 95% CL: Not applicable
- Mortality:
- No mortality was observed in the male and female group dosed with 3100 mg/kg bw 2/5 males and 2/5 females dosed with 5000 mg/kg bw died within the first week post application.
- Clinical signs:
- Rats of both sex and in both dose groups suffered from weight loss, rough fur, bloody snout and reduced general condition.
- Body weight:
- weight loss was reported
- Gross pathology:
- Gross autopsy of some of the surviving rats showed no pathological findings.
Any other information on results incl. tables
Dosis | Toxicologicalresults | Time ofdeath | Start ofthesymptoms | ||
mL/kg | Deadanimals | Animalswithsymptoms | Total ofanimalemployed |
|
|
Males | |||||
3.1 | 0 | 3 | 5 |
| 7 d |
5.0 | 2 | 5 | 5 | 2-3d | 24 h |
Females | |||||
3.1 | 0 | 4 | 5 |
|
|
5.0 | 2 | 5 | 5 | 2-6 d | 24 h |
Table 1.Effect of acute oral toxicity test
Applicant's summary and conclusion
- Executive summary:
Löser E (1982)
In order to test the acute oral toxicity of 1,2,3 -trichlorobenzene, 5 male and 5 female tested were dosed by gavage (3100 and 5000 mg/kg bw) with a method similar to OECD guideline 401 with deviations (No analytical purity reported. No GLP. Only 2 dosis tested)
Tthe following toxicological effects were observed:
1) Mortality: no mortality was observed in the male and female group dosed with 3100 mg/kg bw 2/5 males and 2/5 females dosed with 5000 mg/kg bw died within the first week post application.
2) Signs of intoxication
Rats of both sex and in both dose groups suffered from weight loss, rough fur, bloody snout and reduced general condition.
3) Gross autopsy
Gross autopsy of some of the surviving rats showed no pathological findings.
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