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EC number: 205-711-1 | CAS number: 148-24-3
Skin irritation (rabbit): not irritating
Eye irritation (rabbit): corrosive
Table 1 Results of eye irritation
The skin irritancy potential of quinolin-8-ol (CAS 148-24-3) was determined in a skin irritation study in white rabbits (NZW) performed according to GLP and OECD TG 404 (reference 7.3.1-1). The test substance was topically applied to the skin of three rabbits for 4 h. Local reactions were scored at 1, 24, 48 and 72 h. No local reactions were observed (meanerythema and edema scores of 0.0 calculated as mean for all animals over 24, 48 and 72 h). Based on the results of the conducted study,quinolin-8-oldid not exhibit irritating properties towards the skin.
To evaluate the irritation potential towards the eyes, 0.1 g quinolin-8-ol (CAS 148-24-3) was instilled into the eyes of three white rabbits (NZW) similar to OECD TG 405 and GLP criteria (reference 7.3.2-1). The reactions were observed 1 h after substance application and daily from Day 1 up to Day 20. Instillation of the test substance into the eyes produced signs of irritation in all animals. In detail, redness and chemosis of the conjunctivae were observed in all test animals. Those effects were fully reversible latest within 168 hours, respectively. Furthermore, 1/3 animals showed corneal opacity which was not reversible until the end of the observation period (20 days). In the 2 remaining animals, no effects on the cornea were determined. No effects on the iris were observed in any test animal. Based on the irreversible corneal lesion observed in 1/3 animals, quinolin-8-ol is considered as corrosive to the eyes.
Based on the available data on skin irritation, quinolin-8-ol does not meet the classification criteria for skin irritation according to Regulation (EC) 1272/2008. The available data on eye irritation with quinolin-8-ol (CAS 148-24-3) meet the criteria for classification as Eye Dam. Cat. 1 (H318) according to Regulation (EC) 1272/2008.
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