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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1981

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Version / remarks:
adopted 24 Feb 1987
Deviations:
no
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Quinolin-8-ol
EC Number:
205-711-1
EC Name:
Quinolin-8-ol
Cas Number:
148-24-3
Molecular formula:
C9H7NO
IUPAC Name:
quinolin-8-ol
Test material form:
solid
Specific details on test material used for the study:
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing: Test substance was grounded into a fine powder.

Test animals

Species:
rat
Strain:
Wistar
Remarks:
SPF
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Winkelmann, Paderborn, Germany
- Weight at study initiation: 160 - 170 g
- Fasting period before study: 16 h
- Housing: Animals were housed individually during observation period
- Diet: Standard diet (tpf) Altromin, ad libitum
- Water: water, ad libitum

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 2
- Humidity (%): 50 - 60
- Photoperiod (hrs dark / hrs light): 12/12

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: Tylose/Tween (1%)
Details on oral exposure:
VEHICLE
- Concentration in vehicle: 6 - 12% (depending on test item concentration)
- Amount of vehicle: 1mL/100 g bw

MAXIMUM DOSE VOLUME APPLIED: 1 mL/100 g bw
Doses:
600 (6% in vehicle), 756 (7.5% in vehicle), 953 (9.5% in vehicle) and 1200 (12% in vehicle) mg/kg bw
No. of animals per sex per dose:
10
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations: at least after 1 and 24 h and 7 and 14 days after treatment (not further specified)
- Frequency of weighing: prior to testing and at the end of the observation period
- Necropsy of survivors performed: yes
Statistics:
Determination of LD50 values according to Litchfield & Wilcoxon and the Gaussian Integral

Results and discussion

Effect levelsopen allclose all
Key result
Sex:
female
Dose descriptor:
LD50
Effect level:
790 mg/kg bw
Based on:
test mat.
Key result
Sex:
male
Dose descriptor:
LD50
Effect level:
800 mg/kg bw
Based on:
test mat.
Mortality:
Mortality was observed in males and females starting at concentrations of 756 and 600 mg/kg bw, respectively (for further details, please refer to Table 1).
Clinical signs:
other: 600 mg/kg bw: listlessness, ataxia, lying on side, abdominal pain 756 mg/kg bw: sedation, exophthalmus, staggering, abdominal pain, straggly fur, soft faeces, significantly diminished reflexes 953 mg/kg bw: sedation, staggering, exophthalmus, abdominal pa
Gross pathology:
Surviving animals:
600 mg/kg bw: lobular pattern of the liver and gritty or mottled kidneys
756 mg/kg bw: hyperemia of stomach and small intestine, lobular pattern of the liver and gritty or mottled kidneys
953 mg/kg bw: hyperemia of small intestine, slight to pronounced lobular pattern of the liver and mottled or gritty kidneys
Other findings:
Macroscopic findings summarised for all groups:
stomach: light red to bloody-red (mucous membranes hyperaemised)
small/large intestine: light pink to bloody-red (mucous membranes hyperaemised)

Any other information on results incl. tables

Table 1 Results of Mortality

Dose Mortality
24 h
Mortality
7 d
Mortality
14 d
[mg/kg bw]
  N* N* N*
Males
600 0/10 0/10 0/10
756 2/10 3/10 3/10
953 8/10 9/10 9/10
1200 10/10 10/10 10/10
Females
600 0/10 1/10 1/10
756 3/10 3/10 3/10
953 7/10 9/10 9/10
1200 9/10 10/10 10/10

N* = number of animals

Table 2 Resulst of average body weight

Dose [mg/kg bw] Average starting body weight [g] Average body weight [g] after 14 days
600 165.2±4.54 202.1±9.46
756 165.2±4.21 192.6±19.16
953 163.8±3.74 175.0
1200 164.3±4.32 -

Applicant's summary and conclusion

Interpretation of results:
Category 3 based on GHS criteria
Conclusions:
Although the available data on acute oral toxicity meet the classification criteria for Acute toxicity Category 4, H302 according to Regulation (EC) No 1272/2008, the registrant follows the suggested classification defined in the RAC opinion for Acute toxicity Category 3, H301 according to Regulation (EC) No 1272/2008.