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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
October 1992 - January 1993
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
GLP compliance:
yes
Type of method:
column elution method
Key result
Water solubility:
40.8 mg/L
Temp.:
20 °C
pH:
>= 5.61 - <= 5.92

Measurements of water solubility at 20 °C

    Time (days)      
 held  equilibrated  Concentration  Mean Concentration  pH
 at 30 °C  at 20 °C  (mg/L)  (mg/L)  
 1  1

43.4 

 43.4

 43.4  5.61
 2  1  37.8  38.2  38.0  5.62
 3  1  40.9  40.9  40.9  5.92
Mean = 40.8 ± 2.4 mg/L          

 

Conclusions:
Interpretation of results: slightly soluble (0.1-100 mg/L)
The water solubility of 1,3-bis(3-methyl-2,5-dioxo-1H-pyrrolinylmethyl)benzene was determined at 40.8 mg/L at 20 °C.
Executive summary:

The water solubility of 1,3-bis(3-methyl-2,5-dioxo-1H-pyrrolinylmethyl)benzene was determined to according to OECD method 105, EU method A.6. With the Flask shaking/column elution method the solubility was determined at 40.8 mg/L at 20 °C.

Wheaton vials containing 50 mg of 1,3-bis(3-methyl-2,5-dioxo-1H-pyrrolinylmethyl)benzene and 50 mL of distilled water were purged with nitrogen, sealed and shaken at 30 °C for 1, 2 and 3 days. On each occasion one vial was transferred to equilibrate at 20 °C for 24 hours. The samples were then filtered through 0.2 µ PTFE filters and the concentration of 1,3-bis(3-methyl-2,5-dioxo-1H-pyrrolinylmethyl)benzene determined by HPLC employing UV detection.

Description of key information

The water solubility of 1,3-bis(3-methyl-2,5-dioxo-1H-pyrrolinylmethyl)benzene was determined

to be 40.8 mg/L at 20 °C.

Key value for chemical safety assessment

Water solubility:
40.8 mg/L
at the temperature of:
20 °C

Additional information