Registration Dossier

Administrative data

Endpoint:
repeated dose toxicity: inhalation, other
Type of information:
other: review used for justification of DNEL derivation
Adequacy of study:
other information
Reliability:
other: review used for justification of DNEL derivation
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
Nickel and cobalt ions are carcinogenic, therefore no safe reference value for the alveolar dust fractions were derived. Instead in accordance to the German Exposure-Risk-Relationship (ERB) concept for carcinogenic substances, an acceptance concentration linked to an additional carcinogenic risk of 1:10,000, and a tolerable concentration, linked to a carcinogenic risk of 1:1,000, have been derived and are used for risk management under German legislation for hazardous substances (Technical Rules for Hazardous Substances TRGS 910 and TGRS 561). For nickel compounds furthermore an OEL for the inhalable fraction was derived.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Cobalt-Metall und anorganische Cobalt-Verbindungen (gilt nur für A-Staub)
Author:
AGS
Year:
2017
Bibliographic source:
Begründung zu Cobalt und Verbindungen in TRGS 910 (Fassung v. 13.10.2017)
Reference Type:
publication
Title:
Nickelmetall (CAS-Nr.: 7440-02-0)
Author:
AGS
Year:
2015
Bibliographic source:
Begründung zu Nickelmetall in TRGS 900 (Fassung v. 10.11.2015)

Materials and methods

Results and discussion

Applicant's summary and conclusion