Lithium Nickel Cobalt Aluminium Oxide

Repeated dose toxicity: inhalation

Administrative data

Endpoint:

repeated dose toxicity: inhalation, other

Type of information:

other: review used for justification of DNEL derivation

Adequacy of study:

other information

Reliability:

other: review used for justification of DNEL derivation

Rationale for reliability incl. deficiencies:

secondary literature

Justification for type of information:

Nickel and cobalt ions are carcinogenic, therefore no safe reference value for the alveolar dust fractions were derived. Instead in accordance to the German Exposure-Risk-Relationship (ERB) concept for carcinogenic substances, an acceptance concentration linked to an additional carcinogenic risk of 1:10,000, and a tolerable concentration, linked to a carcinogenic risk of 1:1,000, have been derived and are used for risk management under German legislation for hazardous substances (Technical Rules for Hazardous Substances TRGS 910 and TGRS 561). For nickel compounds furthermore an OEL for the inhalable fraction was derived.

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Cobalt-Metall und anorganische Cobalt-Verbindungen (gilt nur für A-Staub)

Author:

AGS

Year:

2017

Bibliographic source:

Begründung zu Cobalt und Verbindungen in TRGS 910 (Fassung v. 13.10.2017)

Reference 2

Reference Type:

publication

Title:

Nickelmetall (CAS-Nr.: 7440-02-0)

Author:

AGS

Year:

2015

Bibliographic source:

Begründung zu Nickelmetall in TRGS 900 (Fassung v. 10.11.2015)