Registration Dossier
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EC number: 700-042-6 | CAS number: 177997-13-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- repeated dose toxicity: inhalation, other
- Type of information:
- other: review used for justification of DNEL derivation
- Adequacy of study:
- other information
- Reliability:
- other: review used for justification of DNEL derivation
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Nickel and cobalt ions are carcinogenic, therefore no safe reference value for the alveolar dust fractions were derived. Instead in accordance to the German Exposure-Risk-Relationship (ERB) concept for carcinogenic substances, an acceptance concentration linked to an additional carcinogenic risk of 1:10,000, and a tolerable concentration, linked to a carcinogenic risk of 1:1,000, have been derived and are used for risk management under German legislation for hazardous substances (Technical Rules for Hazardous Substances TRGS 910 and TGRS 561). For nickel compounds furthermore an OEL for the inhalable fraction was derived.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Cobalt-Metall und anorganische Cobalt-Verbindungen (gilt nur für A-Staub)
- Author:
- AGS
- Year:
- 2 017
- Bibliographic source:
- Begründung zu Cobalt und Verbindungen in TRGS 910 (Fassung v. 13.10.2017)
- Reference Type:
- publication
- Title:
- Nickelmetall (CAS-Nr.: 7440-02-0)
- Author:
- AGS
- Year:
- 2 015
- Bibliographic source:
- Begründung zu Nickelmetall in TRGS 900 (Fassung v. 10.11.2015)
Materials and methods
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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