Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Conducted at GLP-accredited facility to current guidelines

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2008

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficient
Type:
log Pow
Partition coefficient:
ca. 6.27
Temp.:
30 °C
pH:
7.1
Details on results:
The retention time of the test material (22.609 , 22.589 minutes) was slightly shorter than that of the most retained reference substance (DDT, 23.768 minutes). The log10Pow for DDT is 6.5. The calibration curve was linear over the range of reference chemicals, with a correlation coefficient of 0.997.

Applicant's summary and conclusion

Conclusions:
The partition coefficient of the test material has been determined to be 1.84 x 106 , log10 Pow 6.27.
Executive summary:

The partition coefficient of the test material has been determined to be 1.84 x 106, log10Pow6.27, unsing HPLC method, Method A8 of Commission Directive 92/69/EEC.