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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Study period:
2012
Reliability:
1 (reliable without restriction)
Justification for type of information:
The read-across of data from chemical source (triethyl orthoformate) to chemical target (Tetraethyl orthocarbonate) is based on the following hypothesis:
- chemical source and chemical target have the same organic functional groups; the only difference is the aliphatic carbon of the chemical source no judged relevant for this evaluation
- chemical source and chemical target have a very close structure similarity
- chemical source and chemical target have similar flash point and boiling point
Cross-reference
Reason / purpose for cross-reference:
read-across source
Reference
Endpoint:
acute toxicity: inhalation
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Study period:
2012
Reliability:
1 (reliable without restriction)
Justification for type of information:
The read-across of data from chemical source (triethyl orthoformate) to chemical target (Tetraethyl orthocarbonate) is based on the following hypothesis:
- chemical source and chemical target have the same organic functional groups; the only difference is the aliphatic carbon of the chemical source no judged relevant for this evaluation
- chemical source and chemical target have a very close structure similarity
- chemical source and chemical target have similar flash point and boiling point
Reason / purpose for cross-reference:
read-across source
Principles of method if other than guideline:
Read-across of data from chemical source (triethyl orthoformate) to chemical target (Tetraethyl orthocarbonate)
GLP compliance:
not specified
Key result
Sex:
not specified
Dose descriptor:
LC0
Effect level:
ca. 26 mg/L air
Based on:
not specified
Exp. duration:
8 h
Remarks on result:
other:
Remarks:
LCLo value equal to 26,1 mg/L in rat
Interpretation of results:
GHS criteria not met
Conclusions:
No data are available for the tetraethyl orthocarbonate; however, the triethyl orthoformate (a structural analogue substance) has a LCLo value equal to 26,1 mg/L in rat. This parameter has been estimated following to 8h-exposure. The read-across of these data is considered as justified.
Executive summary:

The triethyl orthoformate (a structural analogue substance) has a LCLo value equal to 26,1 mg/L in rat.

Data source

Reference
Reference Type:
secondary source
Title:
Orthoformic acid, triethyl ester
Author:
RTECS® Registry of Toxic Effects of Chemical Substances
Year:
2012
Bibliographic source:
RTECS® Registry of Toxic Effects of Chemical Substances
Report date:
2012

Materials and methods

Test guideline
Qualifier:
no guideline available
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Triethyl orthoformate
EC Number:
204-550-4
EC Name:
Triethyl orthoformate
Cas Number:
122-51-0
Molecular formula:
C7H16O3
IUPAC Name:
1,1',1''-[methanetriyltris(oxy)]triethane
Test material form:
liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
not specified
Remark on MMAD/GSD:
not specified
Details on inhalation exposure:
not specified
Remarks on duration:
not specified
Concentrations:
not specified
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Key result
Sex:
not specified
Dose descriptor:
LC0
Effect level:
ca. 26.1 mg/L air
Based on:
test mat.
Exp. duration:
8 h
Remarks on result:
other:
Remarks:
LCLo value equal to 26,1 mg/L in rat. This parameter has been estimated following to 8h-exposure
Mortality:
not specified
Clinical signs:
other: not specified
Body weight:
not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
No data are available for the tetraethyl orthocarbonate; however, the triethyl orthoformate (a structural analogue substance) has a LCLo value equal to 26,1 mg/L in rat. This parameter has been estimated following to 8h-exposure. The read-across of these data is considered as justified
Executive summary:

The triethyl orthoformate (a structural analogue substance) has a LCLo value equal to 26,1 mg/L in rat.