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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Referenceopen allclose all

Endpoint:
acute toxicity: oral
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Study period:
2012
Reliability:
1 (reliable without restriction)
Justification for type of information:
The read-across of data from chemical source (triethyl orthoformate) to chemical target (Tetraethyl orthocarbonate) is based on the following hypothesis:
- chemical source and chemical target have the same organic functional groups; the only difference is the aliphatic carbon of the chemical source no judged relevant for this evaluation
- chemical source and chemical target have a very close structure similarity
- chemical source and chemical target have similar flash point and boiling point
Reason / purpose for cross-reference:
read-across source
Qualifier:
no guideline available
GLP compliance:
not specified
Species:
rat
Strain:
not specified
Sex:
not specified
Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
not specified
Doses:
not specified
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified
Preliminary study:
not specified
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 7 060 mg/kg bw
Remarks on result:
other:
Remarks:
LD50 value is >2000
Mortality:
not specified
Clinical signs:
not specified
Body weight:
not specified
Gross pathology:
not specified
Other findings:
not specified
Interpretation of results:
GHS criteria not met
Conclusions:
No data are available for the tetraethyl orthocarbonate; however, the triethyl orthoformate (a structural analogue substance) has a LD50 value equal to 7060 mg/kg bw in rat. The read-across of these data is considered as justified.
Executive summary:

The triethyl orthoformate (a structural analogue substance) has a LD50 value equal to 7060 mg/kg bw in rat.

Endpoint:
acute toxicity: oral
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Study period:
2012
Reliability:
1 (reliable without restriction)
Justification for type of information:
The read-across of data from chemical source (triethyl orthoformate) to chemical target (Tetraethyl orthocarbonate) is based on the following hypothesis:
- chemical source and chemical target have the same organic functional groups; the only difference is the aliphatic carbon of the chemical source no judged relevant for this evaluation
- chemical source and chemical target have a very close structure similarity
- chemical source and chemical target have similar flash point and boiling point
Reason / purpose for cross-reference:
read-across source
Principles of method if other than guideline:
Read-across of data from chemical source (triethyl orthoformate) to chemical target (Tetraethyl orthocarbonate)
GLP compliance:
not specified
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 7 060 mg/kg bw
Based on:
not specified
Remarks on result:
other:
Remarks:
LD50 value is 7060 mg/kg bw
Interpretation of results:
GHS criteria not met
Conclusions:
No data are available for substance target (TEC); however, the triethyl orthoformate (a structural analogue substance) has a LD50 value equal to 7060 mg/kg bw in rat. The read-across of these data is considered as justified.
Executive summary:

The triethyl orthoformate (a structural analogue substance) has a LD50 value equal to 7060 mg/kg bw in rat.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
7 060 mg/kg bw

Acute toxicity: via inhalation route

Link to relevant study records

Referenceopen allclose all

Endpoint:
acute toxicity: inhalation
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Study period:
2012
Reliability:
1 (reliable without restriction)
Justification for type of information:
The read-across of data from chemical source (triethyl orthoformate) to chemical target (Tetraethyl orthocarbonate) is based on the following hypothesis:
- chemical source and chemical target have the same organic functional groups; the only difference is the aliphatic carbon of the chemical source no judged relevant for this evaluation
- chemical source and chemical target have a very close structure similarity
- chemical source and chemical target have similar flash point and boiling point
Reason / purpose for cross-reference:
read-across source
Qualifier:
no guideline available
GLP compliance:
not specified
Species:
rat
Strain:
not specified
Sex:
not specified
Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
not specified
Remark on MMAD/GSD:
not specified
Details on inhalation exposure:
not specified
Remarks on duration:
not specified
Concentrations:
not specified
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified
Preliminary study:
not specified
Key result
Sex:
not specified
Dose descriptor:
LC0
Effect level:
ca. 26.1 mg/L air
Based on:
test mat.
Exp. duration:
8 h
Remarks on result:
other:
Remarks:
LCLo value equal to 26,1 mg/L in rat. This parameter has been estimated following to 8h-exposure
Mortality:
not specified
Clinical signs:
other: not specified
Body weight:
not specified
Gross pathology:
not specified
Other findings:
not specified
Interpretation of results:
GHS criteria not met
Conclusions:
No data are available for the tetraethyl orthocarbonate; however, the triethyl orthoformate (a structural analogue substance) has a LCLo value equal to 26,1 mg/L in rat. This parameter has been estimated following to 8h-exposure. The read-across of these data is considered as justified
Executive summary:

The triethyl orthoformate (a structural analogue substance) has a LCLo value equal to 26,1 mg/L in rat.

Endpoint:
acute toxicity: inhalation
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Study period:
2012
Reliability:
1 (reliable without restriction)
Justification for type of information:
The read-across of data from chemical source (triethyl orthoformate) to chemical target (Tetraethyl orthocarbonate) is based on the following hypothesis:
- chemical source and chemical target have the same organic functional groups; the only difference is the aliphatic carbon of the chemical source no judged relevant for this evaluation
- chemical source and chemical target have a very close structure similarity
- chemical source and chemical target have similar flash point and boiling point
Reason / purpose for cross-reference:
read-across source
Principles of method if other than guideline:
Read-across of data from chemical source (triethyl orthoformate) to chemical target (Tetraethyl orthocarbonate)
GLP compliance:
not specified
Key result
Sex:
not specified
Dose descriptor:
LC0
Effect level:
ca. 26 mg/L air
Based on:
not specified
Exp. duration:
8 h
Remarks on result:
other:
Remarks:
LCLo value equal to 26,1 mg/L in rat
Interpretation of results:
GHS criteria not met
Conclusions:
No data are available for the tetraethyl orthocarbonate; however, the triethyl orthoformate (a structural analogue substance) has a LCLo value equal to 26,1 mg/L in rat. This parameter has been estimated following to 8h-exposure. The read-across of these data is considered as justified.
Executive summary:

The triethyl orthoformate (a structural analogue substance) has a LCLo value equal to 26,1 mg/L in rat.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LC50
Value:
26.1 mg/m³

Acute toxicity: via dermal route

Link to relevant study records

Referenceopen allclose all

Endpoint:
acute toxicity: dermal
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Study period:
2012
Reliability:
1 (reliable without restriction)
Justification for type of information:
The read-across of data from chemical source (triethyl orthoformate) to chemical target (Tetraethyl orthocarbonate) is based on the following hypothesis:
- chemical source and chemical target have the same organic functional groups; the only difference is the aliphatic carbon of the chemical source no judged relevant for this evaluation
- chemical source and chemical target have a very close structure similarity
- chemical source and chemical target have similar flash point and boiling point
Reason / purpose for cross-reference:
read-across source
Qualifier:
no guideline available
GLP compliance:
not specified
Species:
rabbit
Strain:
not specified
Sex:
not specified
Type of coverage:
not specified
Vehicle:
not specified
Details on dermal exposure:
not specified
Duration of exposure:
not specified
Doses:
not specified
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 18 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other:
Remarks:
LD50 value is equal to 18000 mg/kg bw
Mortality:
not specified
Clinical signs:
not specified
Body weight:
not specified
Gross pathology:
not specified
Other findings:
not specified
Interpretation of results:
GHS criteria not met
Conclusions:
No data are available for the tetraethyl orthocarbonate; however, the triethyl orthoformate (a structural analogue substance) has a LD50 value equal to 18000 mg/kg bw in rabbit. The read-across of these data is considered as justified
Executive summary:

The triethyl orthoformate (a structural analogue substance) has a LD50 value equal to 18000 mg/kg bw in rabbit.

Endpoint:
acute toxicity: dermal
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Study period:
2012
Reliability:
1 (reliable without restriction)
Justification for type of information:
The read-across of data from chemical source (triethyl orthoformate) to chemical target (Tetraethyl orthocarbonate) is based on the following hypothesis:
- chemical source and chemical target have the same organic functional groups; the only difference is the aliphatic carbon of the chemical source no judged relevant for this evaluation
- chemical source and chemical target have a very close structure similarity
- chemical source and chemical target have similar flash point and boiling point
Reason / purpose for cross-reference:
read-across source
Principles of method if other than guideline:
Read-across of data from chemical source (triethyl orthoformate) to chemical target (Tetraethyl orthocarbonate)
GLP compliance:
not specified
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 18 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other:
Remarks:
LD50 value equal to 18000 mg/kg bw
Interpretation of results:
GHS criteria not met
Conclusions:
No data are available for the tetraethyl orthocarbonate; however, the triethyl orthoformate (a structural analogue substance) has a LD50 value equal to 18000 mg/kg bw in rabbit. The read-across of these data is considered as justified
Executive summary:

The triethyl orthoformate (a structural analogue substance) has a LD50 value equal to 18000 mg/kg bw in rabbit.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
180 000 mg/kg bw

Additional information

Justification for classification or non-classification

Acute toxicity - oral

no data are available for the tetraethyl orthocarbonate; however, the triethyl orthoformate (a structural analogue substance) has a LD50 value equal to 7060 mg/kg bw in rat. The read-across of these data is considered as justified.Overall, This end-point is judged as concl no class.

Acute toxicity - dermal

no data are available for the tetraethyl orthocarbonate; however, the triethyl orthoformate (a structural analogue substance) has a LD50 value equal to 18000 mg/kg bw in rabbit. The read-across of these data is considered as justified. Overall, This end-point is judged as concl no class.

Acute toxicity - inhalation

no data are available for the tetraethyl orthocarbonate; however, the triethyl orthoformate (a structural analogue substance) has a LCLo value equal to 26,1 mg/L in rat. This parameter has been estimated following to 8h-exposure. The read-across of these data is considered as justified. Overall, This end-point is judged as concl no class.