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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Study period:
2012
Reliability:
1 (reliable without restriction)
Justification for type of information:
The read-across of data from chemical source (triethyl orthoformate) to chemical target (Tetraethyl orthocarbonate) is based on the following hypothesis:
- chemical source and chemical target have the same organic functional groups; the only difference is the aliphatic carbon of the chemical source no judged relevant for this evaluation
- chemical source and chemical target have a very close structure similarity
- chemical source and chemical target have similar flash point and boiling point
Cross-reference
Reason / purpose:
read-across source
Reference
Endpoint:
acute toxicity: oral
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Study period:
2012
Reliability:
1 (reliable without restriction)
Justification for type of information:
The read-across of data from chemical source (triethyl orthoformate) to chemical target (Tetraethyl orthocarbonate) is based on the following hypothesis:
- chemical source and chemical target have the same organic functional groups; the only difference is the aliphatic carbon of the chemical source no judged relevant for this evaluation
- chemical source and chemical target have a very close structure similarity
- chemical source and chemical target have similar flash point and boiling point
Reason / purpose:
read-across source
Principles of method if other than guideline:
Read-across of data from chemical source (triethyl orthoformate) to chemical target (Tetraethyl orthocarbonate)
GLP compliance:
not specified
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 7 060 mg/kg bw
Based on:
not specified
Remarks on result:
other:
Remarks:
LD50 value is 7060 mg/kg bw
Interpretation of results:
GHS criteria not met
Conclusions:
No data are available for substance target (TEC); however, the triethyl orthoformate (a structural analogue substance) has a LD50 value equal to 7060 mg/kg bw in rat. The read-across of these data is considered as justified.
Executive summary:

The triethyl orthoformate (a structural analogue substance) has a LD50 value equal to 7060 mg/kg bw in rat.

Data source

Reference
Reference Type:
secondary source
Title:
Orthoformic acid, triethyl ester
Author:
RTECS® Registry of Toxic Effects of Chemical Substances
Year:
2012
Bibliographic source:
RTECS® Registry of Toxic Effects of Chemical Substances
Report Date:
2012

Materials and methods

Test guideline
Qualifier:
no guideline available
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
not specified
Doses:
not specified
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 7 060 mg/kg bw
Remarks on result:
other:
Remarks:
LD50 value is >2000
Mortality:
not specified
Clinical signs:
not specified
Body weight:
not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
No data are available for the tetraethyl orthocarbonate; however, the triethyl orthoformate (a structural analogue substance) has a LD50 value equal to 7060 mg/kg bw in rat. The read-across of these data is considered as justified.
Executive summary:

The triethyl orthoformate (a structural analogue substance) has a LD50 value equal to 7060 mg/kg bw in rat.