Registration Dossier
Registration Dossier
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EC number: 201-082-2 | CAS number: 78-09-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 2012
- Reliability:
- 1 (reliable without restriction)
- Justification for type of information:
- The read-across of data from chemical source (triethyl orthoformate) to chemical target (Tetraethyl orthocarbonate) is based on the following hypothesis:
- chemical source and chemical target have the same organic functional groups; the only difference is the aliphatic carbon of the chemical source no judged relevant for this evaluation
- chemical source and chemical target have a very close structure similarity
- chemical source and chemical target have similar flash point and boiling point
Cross-reference
- Reason / purpose for cross-reference:
- read-across source
Reference
- Endpoint:
- acute toxicity: oral
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 2012
- Reliability:
- 1 (reliable without restriction)
- Justification for type of information:
- The read-across of data from chemical source (triethyl orthoformate) to chemical target (Tetraethyl orthocarbonate) is based on the following hypothesis:
- chemical source and chemical target have the same organic functional groups; the only difference is the aliphatic carbon of the chemical source no judged relevant for this evaluation
- chemical source and chemical target have a very close structure similarity
- chemical source and chemical target have similar flash point and boiling point - Reason / purpose for cross-reference:
- read-across source
- Principles of method if other than guideline:
- Read-across of data from chemical source (triethyl orthoformate) to chemical target (Tetraethyl orthocarbonate)
- GLP compliance:
- not specified
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 7 060 mg/kg bw
- Based on:
- not specified
- Remarks on result:
- other:
- Remarks:
- LD50 value is 7060 mg/kg bw
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- No data are available for substance target (TEC); however, the triethyl orthoformate (a structural analogue substance) has a LD50 value equal to 7060 mg/kg bw in rat. The read-across of these data is considered as justified.
- Executive summary:
The triethyl orthoformate (a structural analogue substance) has a LD50 value equal to 7060 mg/kg bw in rat.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Orthoformic acid, triethyl ester
- Author:
- RTECS® Registry of Toxic Effects of Chemical Substances
- Year:
- 2 012
- Bibliographic source:
- RTECS® Registry of Toxic Effects of Chemical Substances
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Triethyl orthoformate
- EC Number:
- 204-550-4
- EC Name:
- Triethyl orthoformate
- Cas Number:
- 122-51-0
- Molecular formula:
- C7H16O3
- IUPAC Name:
- 1,1',1''-[methanetriyltris(oxy)]triethane
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- not specified
- Doses:
- not specified
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 7 060 mg/kg bw
- Remarks on result:
- other:
- Remarks:
- LD50 value is >2000
- Mortality:
- not specified
- Clinical signs:
- not specified
- Body weight:
- not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- No data are available for the tetraethyl orthocarbonate; however, the triethyl orthoformate (a structural analogue substance) has a LD50 value equal to 7060 mg/kg bw in rat. The read-across of these data is considered as justified.
- Executive summary:
The triethyl orthoformate (a structural analogue substance) has a LD50 value equal to 7060 mg/kg bw in rat.
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