Registration Dossier
Registration Dossier
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EC number: 225-918-0 | CAS number: 5146-66-7
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from peer reviewed journal
Data source
Reference
- Reference Type:
- publication
- Title:
- Monograph on fragrance raw material-Geranyl nitrile
- Author:
- José L. Domingo
- Year:
- 1 976
- Bibliographic source:
- Food and Cosmetics Toxicology Volume 14, Supplement, 1976, Pages 787
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Skin irritation study was carried out in human subjects to evaluate its irritation potential by closed patch test.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 3,7-dimethylocta-2,6-dienenitrile
- EC Number:
- 225-918-0
- EC Name:
- 3,7-dimethylocta-2,6-dienenitrile
- Cas Number:
- 5146-66-7
- Molecular formula:
- C10H15N
- IUPAC Name:
- 3,7-dimethylocta-2,6-dienenitrile
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): GERANYL NITRILE
- Molecular formula: C10H15N
- Molecular weight: 149.236 g/mol
- Smiles notation : N#C\C=C(\CC\C=C(\C)C)C
- InChl: 1S/C10H15N/c1-9(2)5-4-6-10(3)7-8-11/h5,7H,4,6H2,1-3H3/b10-7+
- Substance type: Organic
- Physical state: Liquid
Constituent 1
Test animals
- Species:
- human
- Strain:
- other: Not applicable
- Details on test animals or test system and environmental conditions:
- No details available
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- other: Petrolatum
- Controls:
- not specified
- Amount / concentration applied:
- 12% in petrolatum
- Duration of treatment / exposure:
- 48-hours
- Observation period:
- 48-hours
- Number of animals:
- No data
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 48 hrs
- Reversibility:
- no data
- Remarks on result:
- other: Not irritating
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Conclusions:
- In skin irritation study of Geranyl nitrile ,the chemical was considered to be non-irritating when applied to human skin.
- Executive summary:
Skin irritation study was performed in human subjects for test chemical Geranyl nitrile to evaluate its skin irritation potential by closed patch test.
The test chemical was applied fo 48 hours occlusion period at concentration of 12% in petrolatum and observations were made.
After 48 hours it was observed that the chemical failed to elicit any kind of skin irritation reaction. Therefore, Geranyl nitrile (CAS No: 5146 -66 -7) was considered to be not irritating in human subjects.
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