3,7-dimethylocta-2,6-dienenitrile

Short-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

calculation (if not (Q)SAR)

Remarks:

Migrated phrase: estimated by calculation

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Qualifier:

according to guideline

Guideline:

other: Modeling database

Principles of method if other than guideline:

Data from modeling database ECOSAR v1.1

GLP compliance:

no

Test organisms (species):

Daphnia magna

Test type:

static

Water media type:

freshwater

Total exposure duration:

48 h

Duration:

48 h

Dose descriptor:

LC50

Effect conc.:

3.847 mg/L

Nominal / measured:

estimated

Conc. based on:

test mat.

Basis for effect:

not specified

Validity criteria fulfilled:

not specified

Conclusions:

The predicted data suggests the lethal concentration (LC50) for the Citralva (CAS no: 5146-66-7) was estimated to be 3.847mg/L.Based on the result citralva was considered as to be classified in chronic category 2 as per CLP regulations.

Executive summary:

48 hrs aquatic toxicity study (EPI suite, ECOSAR version 1.1, 2016) were conducted to assess toxic effects ofCitralva (CAS no5146-66-7)and the results were predicted. The study was based on the effects of the test compound on the Daphnia magna in a static fresh water system. The predicted data suggests the lethal concentration (LC50) for theCitralva (CAS no5146-66-7) was estimated to be 3.847mg/L.Based on the result citralva was considered as to be classified in chronic category 2 as per CLP regulations.

Description of key information

48 hrs aquatic toxicity study (EPI suite, ECOSAR version 1.1, 2016) were conducted to assess toxic effects of 3,7-dimethylocta-2,6-dienenitrile (CAS no 5146-66-7) and the results were predicted. The study was based on the effects of the test compound on the Daphnia magna in a static fresh water system. The predicted data suggests the lethal concentration (LC50) for the 3,7-dimethylocta-2,6-dienenitrile (CAS no 5146-66-7) was estimated to be 3.847 mg/L. As based on the above predicted data  it can be considered that 3,7-dimethylocta-2,6-dienenitrile (CAS no 5146-66-7) is likely to be toxic to aquatic invertebrates can beclassified in aquatic chronic 2 categories as per CLP regulation.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates

Effect concentration:

3.847 mg/L

Additional information

Various predicted studies and read across study for the3,7-dimethylocta-2,6-dienenitrilewere reviewed to summarize the following information: 

48 hrs aquatic toxicity study (EPI suite, ECOSAR version 1.1, 2016) were conducted to assess toxic effects of3,7-dimethylocta-2,6-dienenitrile (CAS no5146-66-7)and the results were predicted. The study was based on the effects of the test compound on the Daphnia magna in a static fresh water system. The predicted data suggests the lethal concentration (LC50) for the3,7-dimethylocta-2,6-dienenitrile (CAS no5146-66-7)was estimated to be 3.847mg/L.

 

Using similar experimental conditions, 48 hrs aquatic toxicity studies (SSS QSAR prediction model, 2016) were conducted to assess toxic effects of3,7-dimethylocta-2,6-dienenitrile (CAS no5146-66-7)and the results were predicted. The study was based on the effects of the test compound on the Daphnia magna in a static fresh water system. The predicted data suggests the effective concentration (EC50) for the3,7-dimethylocta-2,6-dienenitrile (CAS no5146-66-7)was estimated to be 2.28 mg/Lon the basis of intoxication.

 

The acute toxicity test of 3,7-dimethylocta-2,6-dienenitrile was performed on daphnia according to OECD guideline 202 in closed vessel. The exposure duration of chemical was 24 and 48 hr. The 24-h EC50 value was determined to be 26 mg/L and 48-h EC50 found to be 7.66 mg/L. The NOEC value for 48h was determined to be 3.13mg/l.

As based on the above predicted data and read across study, it can be considered that 3,7-dimethylocta-2,6-dienenitrile (CAS no 5146-66-7) is likely to be toxic to aquatic invertebrates can be classified in aquatic chronic 2 categories as per CLP regulation