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EC number: 225-918-0 | CAS number: 5146-66-7
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Qualifier:
- according to guideline
- Guideline:
- other: Modeling database
- Principles of method if other than guideline:
- Data from modeling database ECOSAR v1.1
- GLP compliance:
- no
- Test organisms (species):
- Daphnia magna
- Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 48 h
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 3.847 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- test mat.
- Basis for effect:
- not specified
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The predicted data suggests the lethal concentration (LC50) for the Citralva (CAS no: 5146-66-7) was estimated to be 3.847mg/L.Based on the result citralva was considered as to be classified in chronic category 2 as per CLP regulations.
- Executive summary:
48 hrs aquatic toxicity study (EPI suite, ECOSAR version 1.1, 2016) were conducted to assess toxic effects ofCitralva (CAS no5146-66-7)and the results were predicted. The study was based on the effects of the test compound on the Daphnia magna in a static fresh water system. The predicted data suggests the lethal concentration (LC50) for theCitralva (CAS no5146-66-7) was estimated to be 3.847mg/L.Based on the result citralva was considered as to be classified in chronic category 2 as per CLP regulations.
Reference
Description of key information
48 hrs aquatic toxicity study (EPI suite, ECOSAR version 1.1, 2016) were conducted to assess toxic effects of 3,7-dimethylocta-2,6-dienenitrile (CAS no 5146-66-7) and the results were predicted. The study was based on the effects of the test compound on the Daphnia magna in a static fresh water system. The predicted data suggests the lethal concentration (LC50) for the 3,7-dimethylocta-2,6-dienenitrile (CAS no 5146-66-7) was estimated to be 3.847 mg/L. As based on the above predicted data it can be considered that 3,7-dimethylocta-2,6-dienenitrile (CAS no 5146-66-7) is likely to be toxic to aquatic invertebrates can beclassified in aquatic chronic 2 categories as per CLP regulation.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 3.847 mg/L
Additional information
Various predicted studies and read across study for the3,7-dimethylocta-2,6-dienenitrilewere reviewed to summarize the following information:
48 hrs aquatic toxicity study (EPI suite, ECOSAR version 1.1, 2016) were conducted to assess toxic effects of3,7-dimethylocta-2,6-dienenitrile (CAS no5146-66-7)and the results were predicted. The study was based on the effects of the test compound on the Daphnia magna in a static fresh water system. The predicted data suggests the lethal concentration (LC50) for the3,7-dimethylocta-2,6-dienenitrile (CAS no5146-66-7)was estimated to be 3.847mg/L.
Using similar experimental conditions, 48 hrs aquatic toxicity studies (SSS QSAR prediction model, 2016) were conducted to assess toxic effects of3,7-dimethylocta-2,6-dienenitrile (CAS no5146-66-7)and the results were predicted. The study was based on the effects of the test compound on the Daphnia magna in a static fresh water system. The predicted data suggests the effective concentration (EC50) for the3,7-dimethylocta-2,6-dienenitrile (CAS no5146-66-7)was estimated to be 2.28 mg/Lon the basis of intoxication.
The acute toxicity test of 3,7-dimethylocta-2,6-dienenitrile was performed on daphnia according to OECD guideline 202 in closed vessel. The exposure duration of chemical was 24 and 48 hr. The 24-h EC50 value was determined to be 26 mg/L and 48-h EC50 found to be 7.66 mg/L. The NOEC value for 48h was determined to be 3.13mg/l.
As based on the above predicted data and read across study, it can be considered that 3,7-dimethylocta-2,6-dienenitrile (CAS no 5146-66-7) is likely to be toxic to aquatic invertebrates can be classified in aquatic chronic 2 categories as per CLP regulation
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