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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data is from peer reviewed journal

Data source

Reference
Reference Type:
publication
Title:
Fragrance raw materials monographs -Geranyl nitrile
Author:
Wohl. A. J
Year:
1976
Bibliographic source:
Food and Cosmetics Toxicology Volume 14, Supplement, 1976, Pages 787

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: refer below principle
Principles of method if other than guideline:
The acute toxicity study has been performed on rats by oral route.
GLP compliance:
not specified
Test type:
other: no data
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
3,7-dimethylocta-2,6-dienenitrile
EC Number:
225-918-0
EC Name:
3,7-dimethylocta-2,6-dienenitrile
Cas Number:
5146-66-7
Molecular formula:
C10H15N
IUPAC Name:
3,7-dimethylocta-2,6-dienenitrile
Test material form:
other: Liquid
Details on test material:
- Name of test material (as cited in study report): GERANYL NITRILE
- Molecular formula (if other than submission substance): C10H15N
- Molecular weight (if other than submission substance): 149.236 g/mole
- Smiles notation (if other than submission substance): N#C\C=C(\CC\C=C(\C)C)C
- InChl (if other than submission substance): 1S/C10H15N/c1-9(2)5-4-6-10(3)7-8-11/h5,7H,4,6H2,1-3H3/b10-7+
- Substance type: Organic
- Physical state: Liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No details available

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
No data
Doses:
No data
No. of animals per sex per dose:
No data
Control animals:
not specified
Details on study design:
No details available
Statistics:
No data

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
3 100 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50 % mortaltiy
Mortality:
50% mortality occurred
Clinical signs:
No data
Body weight:
No data
Gross pathology:
No data
Other findings:
No data

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The LD50 value for test chemical Geranyl nitrile was found to be 3100 mg/kg when exposed to rat by oral route.
Executive summary:

The acute toxicity study has been conducted on rats by oral route for the chemical Geranyl nitrile.The LD50 value was found to be 3100 mg/kg when exposed to rat by oral route.