Registration Dossier
Registration Dossier
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EC number: 230-291-1 | CAS number: 7011-83-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- No data provided
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- Principles of method if other than guideline:
- The test substance was orally applied to rats. Mortality was screened for 14 days.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 5-hexyldihydro-5-methylfuran-2(3H)-one
- EC Number:
- 230-291-1
- EC Name:
- 5-hexyldihydro-5-methylfuran-2(3H)-one
- Cas Number:
- 7011-83-8
- Molecular formula:
- C11H20O2
- IUPAC Name:
- 5-hexyldihydro-5-methylfuran-2(3H)-one
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data provided.
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- No data provided.
- Doses:
- 5000 mg/kg
- No. of animals per sex per dose:
- 10 animals (no sex distribution stated)
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: daily
- Necropsy of survivors performed: no data
- Other examinations performed: clinical signs - Statistics:
- No data provided.
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 1 animal died 4 days after treatment.
- Clinical signs:
- other: Rats were slightly lethargic.
- Gross pathology:
- No data provided.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test substance had a acute oral LD50 of greater than 5000 mg/kg bw in rats.
- Executive summary:
A test for acute oral toxicity was done in rats. The animals were observed for 14 days after treatment. One rat died after 4 days and all animals showed slight lethargy. The acute oral LD50 for rats was established to be greater than 5000 mg/kg bw.
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