5-hexyldihydro-5-methylfuran-2(3H)-one

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2016-02-08 to 2016-02-15

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Version / remarks:

1995

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

flask method

Key result

Water solubility:

419 mg/L

Conc. based on:

test mat.

Incubation duration:

>= 24 - <= 72 h

Temp.:

20 °C

pH:

6.4

Details on results:

The concentration measured did not differ for more than 15 % and Temperatures were kept constant within ± 0.5 °C. Thus, all validity criteria were fulfilled.
No Tyndall-effect was observed in all replicates at all time points (24h, 48h, 72h).

pH-value of the Test Mixture

Test temperature [°C]	Preincubation time [h]	Replicate	Measured pH	Mean value (without control)
20	24	1	6.429	6.4
		2	6.255
	48	1	6.465
		2	6.262
	72	1	6.644
		2	6.228
		Control	6.592

 

Water Solubility Results at 20 °C

Preincubation time	Replicate No.	Concentration [mg/L]	Mean [mg/L]
24 h	1	426	422
	2	418
48 h	1	417	421
	2	426
72 h	1	405	413
	2	421
Mean (24-72 h)			419
Deviation[%] (24-72 h)			2.2

 

Conclusions:

The water solubility of the test substance was determined to be 419 mg/L at 20 °C.

Executive summary:

The water solubility was determined according to OECD guideline 105 (1995) and Council Regulation (EC) No. 440/2008 (2014), Method A.6. The solubility of the test item in double distilled water was determined employing the flask method at 20 ± 0.5 °C with preincubation at 30 ± 0.5 °C for 72, 48 and 24 h. The analytical method (HPLC-DAD) for the determination of the test item was validated and tested with satisfactory results in regard to linearity, accuracy, precision and specificity. The water solubility of the test substance was determined to be 419 mg/L at 20 °C.

Description of key information

The water solubility of the test substance was determined to be 419 mg/L at 20 °C.

Key value for chemical safety assessment

Water solubility:

419 mg/L

at the temperature of:

20 °C

Additional information

The water solubility was determined according to OECD guideline 105 (1995) and Council Regulation (EC) No. 440/2008 (2014), Method A.6. The solubility of the test item in double distilled water was determined employing the flask method at 20 ± 0.5 °C with preincubation at 30 ± 0.5 °C for 72, 48 and 24 h. The analytical method (HPLC-DAD) for the determination of the test item was validated and tested with satisfactory results in regard to linearity, accuracy, precision and specificity. The water solubility of the test substance was determined to be 419 mg/L at 20 °C.