Registration Dossier
Registration Dossier
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EC number: 230-291-1 | CAS number: 7011-83-8
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- No data provided.
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
- Endpoint addressed:
- skin irritation / corrosion
- Principles of method if other than guideline:
- The 2 % test substance was applied under occlusion to forearm or back of volunteers for 48 h.
- GLP compliance:
- no
Test material
- Reference substance name:
- 5-hexyldihydro-5-methylfuran-2(3H)-one
- EC Number:
- 230-291-1
- EC Name:
- 5-hexyldihydro-5-methylfuran-2(3H)-one
- Cas Number:
- 7011-83-8
- Molecular formula:
- C11H20O2
- IUPAC Name:
- 5-hexyldihydro-5-methylfuran-2(3H)-one
Constituent 1
Method
- Ethical approval:
- not specified
- Details on study design:
- The 2 % test substance was applied under occlusion to forearm or back of 25 volunteers for 48 h.
- Exposure assessment:
- not specified
- Details on exposure:
- TYPE OF EXPOSURE: patch, occlusive, on skin
EXPOSURE PERIOD: 48 h
Results and discussion
- Results:
- All volunteers remained without any skin reaction after the 48 h exposure.
Applicant's summary and conclusion
- Conclusions:
- The 2 % test substance was not skin irritating to humans.
- Executive summary:
The pre test of the maximization test showed that the 2 % test substance had no skin irritation properties. An occlusive application of the test substance without additional treatment was done. The patches on skin (forearm or back) were applied for 48 h. All 25 volunteers remained without any skin reaction. Therefore the test substance was considered not irritating in humans.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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