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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Description of key information

When a freshwater invertebrate species, Ceriodaphnia dubia, was exposed to phenol, a major component of the reaction mass of phenol and 4,4’-isopropylidenediphenol (referred to henceforth as “the reaction mass”), the 48-hour EC50 value was 3.1 mg/L. When a saltwater species, the mysid shrimp (Americamysis bahia), was exposed to Bisphenol A (a.k.a. 4,4’-isopropylidenediphenol, which is the other major component of the reaction mass), the 96-hour EC50 value was 1.1 mg/L.  These results were selected as key studies, since they were from valid toxicity tests that reported the lowest EC50 values for these parameters.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
3.1 mg/L

Marine water invertebrates

Marine water invertebrates
Effect concentration:
1.1 mg/L

Additional information

One 48-hour acute invertebrate study with Daphnia magna was available for 2-acetone, polymer with phenol, a mixture of some of the major and minor components of the reaction mass of phenol and 4,4’-isopropylidenediphenol (referred to henceforth as “the reaction mass”). This study was deemed reliable for use in risk assessments (Klimish score = 1), and the 48-hour EC50 value was 8.27 mg/L. Additionally, invertebrate acute toxicity tests with the two major components of the reaction mass, phenol and 4,4’-isopropylidenediphenol (a.k.a Bisphenol A), were available as supporting toxicity studies. The 48-hour study conducted with phenol and using the freshwater invertebrate Ceriodaphnia dubia was considered valid with a Klimish score of 2. The 48-hour EC50 for C. dubia exposed to phenol is 3.1 mg/L. The 48-hour study conducted with Bisphenol A and using the freshwater invertebrate Daphnia magna was considered valid with a Klimish score of 1. The 48-hour EC50 for D. magna exposed to Bisphenol A is 10.2 mg/L. The 96-hour study conducted with Bisphenol A and using the saltwater invertebrate Americamysis bahia (mysid shrimp) was considered valid with a Klimish score of 1. The 96-hour EC50 for the mysid shrimp (A. bahia) exposed to Bisphenol A is 1.1 mg/L.  

The 96-hour EC50 of 1.1 mg/L Bisphenol A with the mysid shrimp was the lowest, and thus most conservative, invertebrate acute toxicity value reported for either the major components or a mixture of some of the major and minor components of the reaction mass.