Registration Dossier
Registration Dossier
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EC number: 440-240-7 | CAS number: 1282554-35-1
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
Test material
- Reference substance name:
- -
- EC Number:
- 440-240-7
- EC Name:
- -
- Cas Number:
- 1282554-35-1
- Molecular formula:
- C19 H20 N4
- IUPAC Name:
- 2-Propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 000 mg/kg bw
- Mortality:
- No mortality occurred.
- Clinical signs:
- Red staining of the fur on the head was Seen in two males and one female on day 2. Red staining of the fur is regularly Seen in rats used in this type of dermal toxicity studies. During periods of Stress red discoloured liquid may come out of the nose and eyes of the animals and is spread over the fur by grooming.Focal erythema was observed in the treated skin area of one fernale. Green staining on the back was observed in two rnales and orange staining on the back or flank in four fernales during the observation period.
- Body weight:
- Body weight gain during the observation period was within the range expected for rats used in this type of study.
- Gross pathology:
- No abnormalities were found in the animals at macroscopic post mortem examination.
Applicant's summary and conclusion
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