Registration Dossier
Registration Dossier
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EC number: 203-738-3 | CAS number: 110-13-4
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Study period:
- 1991
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 991
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Hexane-2,5-dione
- EC Number:
- 203-738-3
- EC Name:
- Hexane-2,5-dione
- Cas Number:
- 110-13-4
- Molecular formula:
- C6H10O2
- IUPAC Name:
- hexane-2,5-dione
- Test material form:
- not specified
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- 75-90 days old female Wistar rats
170-200 g body weight
12 hour light/dark cycle
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: 120 mM NaCl, 10 mM K-Phosphate
- Details on exposure:
- 1 mL/kg bw intraperitoneal in vehicle (120 mM NaCl, 10 mM K-Phosphate, pH = 7.2)
- Doses:
- 200, 400, 800 mg/kg bw
- No. of animals per sex per dose:
- 15 -17 female rats per group
- Control animals:
- other: vehicle
- Details on study design:
- nociception measure at 10, 30, 60 an 90 minutes after dosing
a tail-flick-apparatus was used for the experiment (tail-flick latencies) - Statistics:
- ANOVA
Results and discussion
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- other: nociception
- Effect level:
- ca. 200 mg/kg bw
- Based on:
- test mat.
- Sex:
- female
- Dose descriptor:
- other: analgesia
- Effect level:
- ca. 400 mg/kg bw
- Based on:
- test mat.
- Mortality:
- no
- Clinical signs:
- antinociception, analgesia
- Body weight:
- no data
- Gross pathology:
- no data
- Other findings:
- none
Applicant's summary and conclusion
- Conclusions:
- All doses caused antinociception, the high and mid dose at all time points.
800 mg/kg bw: analgesia from 10-60 min
400 mg/kg bw: analgesia from 30-60 min
200 mg/kg bw: antinociception only at 60 min
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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