Registration Dossier

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Documentation insufficient for assessment

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1940

Materials and methods

Test guideline
Qualifier:
no guideline followed
GLP compliance:
not specified
Test type:
other:
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
not specified

Test animals

Species:
guinea pig
Strain:
other: mixed stock
Sex:
female
Details on test animals and environmental conditions:
400-600 g

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
air
Details on inhalation exposure:
chamber temperature 25°C
Analytical verification of test atmosphere concentrations:
yes
Duration of exposure:
> 10 - < 775 min
Concentrations:
saturated vapour, 0.04 % in air
No. of animals per sex per dose:
only one dose group (saturated vapour)
Control animals:
yes
Details on study design:
respiratory rate, pulse and rectal temperature were monitored at 10, 90, 145, 752 and 775 minutes
Statistics:
no data

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
other: irritation, lacrimation
Effect level:
ca. 10 other: minutes
Based on:
other: saturated vapour
Mortality:
none
Clinical signs:
lacrimation, irritation, salivation, watery discharge from the nose
Body weight:
no data
Gross pathology:
not performed

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: OECD GHS
Conclusions:
At the conditions of the experiment no time-concentration-chart could be produced.
The only effect observed is irritation at all time points.