Registration Dossier

Administrative data

Endpoint:
fish short-term toxicity test on embryo and sac-fry stages
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
2002
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Documentation insufficient for assessment

Data source

Reference
Reference Type:
publication
Title:
Entwicklung und Erprobung eines Teratogenitäts-Screening Testes mit Embryonen des Zebrabärblings Danio rerio
Author:
Jean Bachmann
Year:
2002
Bibliographic source:
Dissertation zur Erlangung des akademischen Grades Doctor rerum naturalium (Dr. rer. nat.) an der Fakultät für Forst-, Geo- und Hydrowissenschaften der Technischen Universität Dresden

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
other: Danio rerio Teratogenicity Assay
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
not specified
Details on test material:
> 98 %, Sigma-Aldrich (Steinheim, Germany)

Sampling and analysis

Analytical monitoring:
not specified

Test solutions

Vehicle:
not specified

Test organisms

Test organisms (species):
Danio rerio (previous name: Brachydanio rerio)

Study design

Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
48
Remarks on exposure duration:
h
Post exposure observation period:
48 hours

Test conditions

Nominal and measured concentrations:
10,5; 15,8; 23,7; 35,5 and 53,2 mmol/L

Results and discussion

Effect concentrations
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
ca. 40 other: mmol/L

Applicant's summary and conclusion