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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1971
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1971
Report Date:
1971

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
no
Remarks:
test performed prior to the GLP guidance
Test type:
standard acute method
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Specific details on test material used for the study:
TEST SUBSTANCE
Name (as stated in the report): Labeled 71-39 Benzyl Phenyl Acetate
Aspect : Clear liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female
Details on test animals and environmental conditions:
Not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Doses:
5000ml/kg
No. of animals per sex per dose:
Main study:
5 males and 5 females
Each animal received a 1 dose of 5000 ml/Kg
Control animals:
no
Details on study design:
The animals were observed for 14 days.

Results and discussion

Preliminary study:
Dose 5000 mg/Kg -> No death on 2 animals tested
Dose 1260 mg/Kg -> No death on 2 animals tested
Dose 316 mg/Kg -> No death on 2 animals tested
Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Mortality:
2 deaths on days 2

Any other information on results incl. tables

All rats showed sedation for 24 hours after dosing.

Autopsy revealed no unsual findings

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The LD50 of BENZYL PHENYL ACETATE in rat is likely to be in excess of 5.0 ml/Kg bw. Hence the GHS criteria are not met for classification.
Executive summary:

The substance RIFM 71 -39 BENZYL PHENYL ACETATE was found to have an LD50 in rat greater than 5.000 mg/Kg bw. Hence the GHS criteria are not met for the acute oral classification classification.