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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data from peer- reviewed journal

Data source

Reference
Reference Type:
publication
Title:
Monograph on Benzyl phenylacetate
Author:
Owen
Year:
1979
Bibliographic source:
Food and Cosmetics Toxicology, pg 139, 1979

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: as below
Principles of method if other than guideline:
Acute dermal toxicity study of benzyl phenylacetate in rabbits
GLP compliance:
not specified
Test type:
other: No data
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Name of test material (as cited in study report):Benzyl phenylacetate
Substance type: Organic
Physical state: Liquid
Specific details on test material used for the study:
- Name of test material (as cited in study report): Benzyl phenylacetate
- Molecular formula (if other than submission substance): C15H14O2
- Molecular weight (if other than submission substance): 226.2736 g/mole
- Substance type: Organic

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
No data available

Administration / exposure

Type of coverage:
other: Dermal
Vehicle:
not specified
Details on dermal exposure:
No data available
Duration of exposure:
No data available
Doses:
10950 mg/kg bw
No. of animals per sex per dose:
No data available
Control animals:
not specified
Details on study design:
No data available
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 10 950 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No Mortality observed
Mortality:
No Mortality was observed in treated rabbits at 10950 mg/kg bw
Clinical signs:
No data available
Body weight:
No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
LD50 was considered to be > 10950 mg/kg bw when rabbits were treated with benzyl phenylacetate dermally.
Executive summary:

In a acute oral toxicity study, rabbits were treated with benzyl phenylacetate in the concentration of 10950 mg/kg bw by dermal application. No Mortality was observed in treated rabbits at 10950 mg/kg bw. Therefore, LD50 was considered to be > 10950 mg/kg bw when rabbits were treated with benzyl phenylacetate dermally.