Nonan-2-one

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Data is from peer -reviewed journal

Data source

Reference

Reference Type:

publication

Title:

Fragrance raw materials monographs: 2-nonanone

Author:

Moreno, O. M.

Year:

1988

Bibliographic source:

Food and Chemical Toxicology Volume 26, Issue 4, 1988, Pages 393

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: No data

Principles of method if other than guideline:

Acute dermal toxicity study of nonan-2-one in rabbits

GLP compliance:

no

Test type:

other: No data

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Nonan-2-one

EC Number:

212-480-0

EC Name:

Nonan-2-one

Cas Number:

821-55-6

Molecular formula:

C9H18O

IUPAC Name:

nonan-2-one

Constituent 2

Reference substance name:

2-Nonanone

IUPAC Name:

2-Nonanone

Details on test material:

- Name of test material (as cited in study report): 2-nonanone
- Molecular formula (if other than submission substance): C9H18O
- Molecular weight (if other than submission substance): 142.24g/mol
- Substance type: Organic
- Physical state: colorless to pale yellow clear oily liquid
Purity No data available

Specific details on test material used for the study:

- Name of test material: 2-Nonanone (nonan-2-one )
- IUPAC name: nonan-2 -one
- Molecular formula: C9H18O
- Molecular weight: 142.24g/mol
- Substance type: Organic
- Physical state: No data
- Purity: No data available
- Impurities (identity and concentrations): No data

Test animals

Species:

rabbit

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

No data available

Administration / exposure

Type of coverage:

not specified

Vehicle:

not specified

Details on dermal exposure:

No data available

Duration of exposure:

24 hour

Doses:

5000 mg/kg

No. of animals per sex per dose:

7

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: no data
- Frequency of observations and weighing:no data
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: mortality, clinical signs and gross pathology were observed.

Statistics:

No data available

Results and discussion

Preliminary study:

No data available

Effect levels

Sex:

not specified

Dose descriptor:

LD50

Effect level:

> 5 000 mg/kg bw

Based on:

test mat.

Remarks on result:

other: No mortality was observed in all seven animals.

Mortality:

No mortality was observed in all seven animals.

Clinical signs:

Irritation was observed in treated rabbits at 5000 mg/kg bw

Body weight:

No data available

Gross pathology:

scaly skin was observed in treated rabbits at 5000 mg/kg bw

Other findings:

No data available

Applicant's summary and conclusion

Interpretation of results:

Category 5 based on GHS criteria

Conclusions:

LD50 was considered t be > 5000 mg/kg bw when rabbits were treated with nonan-2-one by dermal application.

Executive summary:

In a acute oral toxicity study, 7 rabbits were treated with nonan-2-one in the concentration of 5000 mg/kg bw orally. No mortality were observed in treated rabbits at 5000 mg/kg bw. Irritation and scaly skin was observed in treated rabbits at 5000 mg/kg bw. Therefore, LD50 was considered t be > 5000 mg/kg bw when rabbits were treated with nonan-2-one by dermal application.