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EC number: 426-200-1 | CAS number: 172015-79-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Adequacy of study:
- other information
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Annex V (B1 bis)
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
Test animals
- Species:
- other: Rat (Wistar)
Administration / exposure
- Vehicle:
- other: Distilled water
- No. of animals per sex per dose:
- Preliminary sighting study: 2 (male)
Preliminary sighting study: 2 (female)
Main study: 5 (male)
Main study: 5 (female)
Results and discussion
- Preliminary study:
- Species/strain: Rat (Wistar)
mg/kg bw: Evident toxicity: ; Mortality:
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- discriminating dose
- Effect level:
- 50 mg/kg bw
- Dose descriptor:
- other: 50 mg/kg bw (fixed dose initial)
- Remarks on result:
- other: No. with evident toxicity: ; No. of deaths: ; No. of animals used:
- Dose descriptor:
- other: 50 mg/kg bw (fixed dose initial)
- Remarks on result:
- other: No. with evident toxicity: ; No. of deaths: 0; No. of animals used: 5
- Clinical signs:
- other: Signs of toxicity: In a preliminary study one male animal died 6 hours after dosing with 500 mg/kg. Clinical signs of toxicity observed in one male and one female were hunched posture, lethargy, pilo-erection, decreased respiratory rate ataxia and in
- Gross pathology:
- Effects on organs:
There were no pathological abnormalitites noted at necropsy
in the main study.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information
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