Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
27 May - 02 September 2010
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Study conducted to internationally accepted guidelines and to GLP.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2010
Report Date:
2010

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Diisoamyl phthalate

- Substance type: organic
- Physical state: liquid
- Analytical purity: 100%


- Lot/batch No.: 7920-1-1
- Expiration date of the lot/batch:12 August 2012

- Storage condition of test material: room temperature in the dark
- Other

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficient
Type:
log Pow
Partition coefficient:
5.6
Temp.:
25 °C
Remarks on result:
other: First and second chromatograms produced the same results. pH not recorded as mobile phase was acetonitrile: water
Details on results:
The mean calibration curve produced was: log10Pow = 3.67 log10k + 3.46

Applicant's summary and conclusion

Conclusions:
Diisoamyl phthalate was found to have a log10Pow value of 5.6.