Registration Dossier

Administrative data

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
27 May - 02 September 2010
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Conducted according to OECD guidelines and GLP

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2010
Report Date:
2010

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
column elution method

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Diisoamyl phthalate

- Substance type: organic
- Physical state: liquid
- Analytical purity: 100%


- Lot/batch No.: 7920-1-1
- Expiration date of the lot/batch:12 August 2012

- Storage condition of test material: room temperature in the dark

Results and discussion

Water solubility
Water solubility:
1.1 mg/L
Temp.:
20 °C
pH:
>= 6.6 - <= 7.1
Details on results:
The detector calibration was found to be linear over the range 0 to 0.8 mg/l of standard solutions in acetonitrile:water (1:1 v/v) with a regression coefficient of 0.9999.
A mean recovery of approximately 80% of Diisoamyl phthalate from fortified control samples prepared at the determined solubility level was achieved and deemed to be acceptable, whilst no significant interfering peaks were evident in blank control solutions.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): slightly soluble (0.1-100 mg/L)
Diisoamyl phthalate was found to have a water solubility of 1.1 mg/l at 20°C.