Registration Dossier

Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

Administrative data

Endpoint:
toxicity to aquatic algae and cyanobacteria
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: (Q)SAR supported by QMRF and QPRF
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
other: Industry accepted software package
Title:
BIOWIN v1.0 (EPI suite)
Author:
Model developed by USEPA
Year:
2008
Bibliographic source:
EPA website

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: REACH guidance on R6, May/June 2008
Principles of method if other than guideline:
Model for determining aquatic toxicity based on Log Kow and water solubility

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
SMILES : CC(C)CCOC(=O)c1c(C(=O)OCCC(C)C)cccc1
CHEMICAL NAME : diisopentyl phthalate
MOL FOR: C18 H26 O4
MOL WT : 306.41
Log Kow: 5.45 (KowWin estimate)
Water Solubility: 0.252 mg/L (WskowWin estimate)

Results and discussion

Effect concentrations
Remarks on result:
other: Predicted data supplied
Details on results:
Validity of the model
1. Defined Endpoint: Short term toxicity to aquatic green algae
2.Acute and chronic aquatic toxicity prediction QSAR. Predicted EC50 at 96 hours is 0.173 mg/L.
3. Applicability domain: Applicable to chemicals with a Log Kow maximum of 6.4. If the log Kow is greater than 6.4, or if the compound is solid and the EC50 exceeds the water solubility by 10X, no effects at saturation are predicted for these endpoints. The QSAR should not be used if the Log Kow is 6.4 or greater or if the molecular weight is 1000 or greater.
4. Statistical characteristics:
5. Mechanistic interpretation based on: Log Kow correlates with the partitioning of the test substance between the aqueous and lipid phases.

Any other information on results incl. tables

An in-life study is currently being conducted and the dossier will be updated once this information is available.

Applicant's summary and conclusion

Conclusions:
Based on the prediction results decriibed Diisoamyl phthalate is predicted to be highly toxic to green algae.
This prediction should be used for classification and labelling.