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EC number: 203-121-9 | CAS number: 103-54-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Two acute oral toxicity studies have been performed, one key study and one supporting study performed on three species. None were following a guideline nor performed under GLP. All results yielded high LD50 values > 3000 mg/kg bw.
One acute dermal toxicity study is available, in which no mortality was observed upon administration of a dermal dose (5000 mg/kg bw) of the test item.
The acute oral and dermal studies are taken together in a weight of evidence approach. The available data show that the substance does not exert acute toxicity, irrespective of the administration route.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 3 300 mg/kg bw
- Quality of whole database:
- The key study on rats has no details on the study design.It was performed similar to OECD TG 401 and pre-GLP.
For the supporting study performed on guinea pigs, rats and mice no guideline has been followed and the study is pre-GLP. There is not much of information available.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
- Quality of whole database:
- The key study on rabbits has no details on the study design and did not follow a guideline. It was performed pre-GLP.
Additional information
Acute toxicity: oral
There are 2 studies available assessing the acute toxicity of the test item via the oral route.
None of these studies is performed according to internationally accepted guidelines or GLP, and the documentation of the test method and results is in general limited. One study (1974) is therefore assigned a Klimisch 4 score. The key study (1972) was assigned a Klimisch score 2. Nevertheless, as the outcome of all studies consistently shows a very low acute toxicity, in addition to the key study the supporting study on several species is used to fulfil the information requirements for this endpoint, and to determine the classification of the test substance. Additional testing is deemed to not bring new information to the acute toxicity assessment, and hence is omitted in order to avoid unnecessary vertebrate animal testing.
The 1974 study addresses the oral acute toxicity to rats, mice and guinea pigs by dosing the test substance dissolved in sunflower-seed oil via oral gavage. 6 Male and 6 female animals were dosed per experiment. The animals were observed for 15 days following the single exposure. Each of these 3 experiments resulted in an LD50 value of 4750 mg/kg bw.
In the second oral toxicity study (key, 1972) the toxicity of the test substance was assessed when administered to rats in four oral doses. The test substance was administered orally to 10 rats per dose, at 1460, 2220, 3330 and 5000 mg/kg body weight. 17 animals died during the study. Slow respiration, lethargy, depression, coarse tremors in high doses, death overnight to 2 days were observed during the 14 days observational period.
The oral LD50 value of the test substance in rats was established as 3300 mg/kg body weight.
The above experiments allow to conclude that the substance exerts only low acute oral toxicity.
Classification according to the CLP Regulation No 1272/2008 is not necessary as the LD50 is higher than 2000 mg/kg bw.
Acute toxicity: dermal
The purpose of the acute dermal study was to assess the toxicity of the test substance when administered to rabbits in one dermal dose. The test substance was administered dermally to 10 rabbits at a dose of 5000 mg/kg body weight. No animal died during the study and no clinical signs could be observed during the 14 days observational period.
The dermal LD50 value of the test substance in rabbits was established as to be greater than 5000 mg/kg body weight.
The acute oral and dermal studies are taken together in a weight of evidence approach. The available data show that the substance does not exert acute toxicity, irrespective of the administration route. As a consequence, classification according to the CLP Regulation No 1272/2008 is not necessary. These results further prove the low acute toxicity of the test substance.
Justification for classification or non-classification
Acute oral toxicity
According to the CLP legislation a substance is considered acute toxic when the acute toxicity estimates (ATE) for the oral route are =< 2000 mg/kg bodyweight. As the LD50 of the test item > 2000 mg/kg bw, the substance has not to be classified as acute toxic for the oral route.
Acute dermal toxicity
According to the CLP legislation a substance is considered acute toxic when the acute toxicity estimates (ATE) for the dermal route are =< 2000 mg/kg bodyweight. As the LD50 of the test item > 2000 mg/kg bw, the substance has not to be classified as acute toxic for the dermal route.
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