Registration Dossier

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1972
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1972
Report date:
1972

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Test animals: rabbit
Number of animals: 10
Sex: not specified
Doses: 1
Period of observation: 14 days post administration
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Cinnamyl acetate
EC Number:
203-121-9
EC Name:
Cinnamyl acetate
Cas Number:
103-54-8
Molecular formula:
C11H12O2
IUPAC Name:
cinnamyl acetate

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Details on dermal exposure:
not specified
Duration of exposure:
not specified
Doses:
5000 mg/kg body weight
No. of animals per sex per dose:
in total 10 animals for one dose
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Mortality:
0/10
Clinical signs:
none
Body weight:
not specified
Gross pathology:
not specified

Applicant's summary and conclusion

Interpretation of results:
other: CLP/EU GHS criteria not met, no classification required according to Regulation (EC) No. 1272/2008.
Conclusions:
The dermal LD50 value of the test substance in rabbits was established as >5000 mg/kg body weight.
Executive summary:

The purpose of this study was to assess the toxicity of the test substance when administered to rabbits in one dermal dose. The test substance was administered dermally to 10 rabbits at a dose of 5000 mg/kg body weight.

No animal died during the study and no clinical signs could be observed during the 14 days observational period.

The dermal LD50 value of the test substance in rabbits was established as to be greater than 5000 mg/kg body weight.