Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 237-928-2 | CAS number: 14075-53-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
A LD50 greater than 2000 mg NaBF4/kg bw (equivalent to 2294 mg KBF4) was observed in the acute oral toxicity study and a LD50 of 5300 mg KBF4/m3 bw was observed in the inhalation toxicity study.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- GLP-compliant guideline study, klimisch 1
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 5 300 mg/m³ air
- Quality of whole database:
- GLP-compliant guideline study, klimisch 1
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
No studies on the acute oral toxicity of potassium tetrafluoroborate are available. However, according to Article 13 of the REACH legislation, in case no appropriate animal studies are available for assessment, information should be generated whenever possible by means other than vertebrate animal tests, i.e. applying alternative methods such as in vitro tests, QSARs, grouping and read-across. One GLP-compliant OECD Guideline 401 study with rats (Safepharm Laboratories Limited, 1992a) is available for a structural analogue of potassium tetrafluoroborate, sodium tetrafluoroborate. A group of 5 male and 5 female rats was administered a single dose of 2000 mg/kg bw in water by gavage. Animals were observed for 14 days and necropsied. There were no deaths or clinical signs of toxicity. All animals gained weight during the study. No pathological findings were revealed at necropsy. Based on the results of the study, the LD50 was above 2000 mg/kg bw. Applying a correction for molecular weight (2/109.79*125.91), a NOAEL of 2294 mg/kg bw/day can be derived for KBF4.
One GLP-compliant acute inhalation study according to OECD Guideline 436 is available for potassium tetrafluoroborate (TNO Triskelion BV, 2012). In this study 3 male and 3 female were submitted to a 4 -hour nose only exposure to an analytical concentration of 5.3 ± 0.7 g/m3 potassium tetrafluoroborate. Animals were observed for 14 days before sacrifice. During the second half of the exposure, all animals showed a slightly decreased breathing rate. No clinical abnormalities were observed approximately one hour after exposure; two hours after exposure soiled fur was seen in two females, one of which also demonstrated lethargic behaviour. One day after exposure, all treatment-related abnormalities had disappeared. After an initial loss of body weight upon exposure normal body weight development was observed 3 days (five animals) and 7 days (one animal) after exposure. No deaths occurred. Macroscopic abnormalities at necropsy were limited to petechiae in single lung lobes of three animals and pale lungs in two other animals. Although it cannot be excluded that these findings were related to the exposure, the minor macroscopic abnormalities in the lungs may well have been part of common background pathology. Based on these findings, the 4-hour LC50 in rats was determined at >5.3 g/m3.
Justification for classification or non-classification
Based on the results of an oral and an inhalation acute toxicity study, the substance does not need to be classified according to the EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
