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Reading across results from EPIKOTE 828 (CAS No. 25068-38-6), the registered substance is considered to be susceptible to hydrolysis at pH 4, 7, and 10, with a hydrolysis half-life of 117 hrs at 25 °C (95% confidence range: 68–204 h). Products of hydrolysis are expected to be the mono-diol and the di-diol from ring-opening of the two epoxy groups.


Also, evidence of hydrolysis of the registered substance was observed during its water solubility test (Štreit, 2010).  A review of “Fig. No. 1:LC/MS analysis of Grilonit 1/10 water solution” in the Annexes reveal that the primary peak (Retention Time = 10.2 mins) fell from ~3.5 to ~2.2 over the course of the 4-day experiment (3 days at 30°C + 1 at 20°C). This amounts to a 37% loss of the primary component over this 96-hour [4 day] period, which is most probably due to ring-opening hydrolysis of the epoxy groups, and compares well with the 50% loss seen for the read-across substance in 117 hrs [~4.9] days at 25°C, further supporting the read-across.