Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-879-2 | CAS number: 75-56-9
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 0.052 mg/L
- Assessment factor:
- 1 000
- Extrapolation method:
- assessment factor
- PNEC freshwater (intermittent releases):
- 0.52 mg/L
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 0.005 mg/L
- Assessment factor:
- 10 000
- Extrapolation method:
- assessment factor
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 10 mg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 0.245 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Sediment (marine water)
- Hazard assessment conclusion:
- PNEC sediment (marine water)
- PNEC value:
- 0.025 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- PNEC soil
- PNEC value:
- 0.019 mg/kg soil dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- no potential for bioaccumulation
Additional information
Conclusion on classification
Initial EU and GHS Hazard classification of Propylene Oxide
The lowest acute aquatic toxicity value is 52 mg/L for the freshwater fish Salmo gairdneri (new name: Oncorhynchus mykiss). Based on the result of the octanol/water partition coefficient (Log Kow of 0.055) propylene oxide is not expected to significantly accumulate in aquatic organisms. Furthermore, the substance is found inherently biodegradable. For these reasons, propylene oxide is not classified in GHS.
PBT AND VPVB ASSESSMENT
An assessment of the PBT status of propylene oxide has been made using all available data. The information available suggests that propylene oxide does not meet the PBT screening criteria as outlined in Annex XIII of Directive 2006/121/EC.
Persistence
Propylene oxide was found ready biodegradable (89% after 28 days) under aerobic conditions in a modified MITI test (MITI 1988) and can therefore be regarded as not persistent.
Bioaccumulation
No experimental data are available for bioaccumulation of propylene oxide.Based on the result of the octanol/water partition coefficient (Log Kow of 0.055) propylene oxide is not expected to significantly accumulate in aquatic organisms.Therefore, propylene oxide can be regarded as not bioaccumulative.
Toxicity
Experimental data on acute toxicity are available for propylene oxide. All acute L(E) C50values are much higher than the screening criterion of 0.1 mg/L. It can therefore be expected that propylene oxide is not toxic towards aquatic organisms. Furthermore, propylene oxide is classified as carcinogenic and mutagenic Cat. 2. Therefore, propylene oxide is assigned as being toxic.
Summary and overall Conclusions on PBT or vPvB Properties
Comparison with the Criteria of Annex XIII An assessment of the PBT status of Propylene oxide has been made using all available data. The information available suggests that PO does not meet the PBT screening criteria as outlined in Annex XIII of Directive 2006/121/EC; that asubstance is identified as a PBT substance if it fulfils the criteria for persistence and for bioaccumulation and for toxicity.
Regarding all available data on biotic and abiotic degradation, bioaccumulation and toxicity it can be stated that the substance does not fulfill the PBT/ vPvB criteria. .
Emission Characterisation
Because the substance does not fulfill the PBT and vPvB criteria, no emission characterisation is performed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
