Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 200-879-2 | CAS number: 75-56-9
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study precedes GLP and OECD guidelines, published in peer-reviewed literature, performed to non-standard protocol, but contributing to assessment.
Data source
Reference
- Reference Type:
- publication
- Title:
- Range finding toxicity data. (List VII).
- Author:
- Smyth HF, Carpenter CP, Weil CS, Pozzani US, Striegel JA and Nycum JS.
- Year:
- 1 969
- Bibliographic source:
- Am. Ind. Hyg. Assoc., 30:470-476.
Materials and methods
- Principles of method if other than guideline:
- Single skin penetration LD50 for rabbits
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Methyloxirane
- EC Number:
- 200-879-2
- EC Name:
- Methyloxirane
- Cas Number:
- 75-56-9
- Molecular formula:
- C3H6O
- IUPAC Name:
- 2-methyloxirane
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Type of coverage:
- open
- Vehicle:
- not specified
- Duration of exposure:
- 4 hours
- Doses:
- pure substance
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
- Statistics:
- no data
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 1.5 mL/kg bw
- Remarks on result:
- other: (950 mg/kg bw)
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
