Registration Dossier
Registration Dossier
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EC number: 219-787-9 | CAS number: 2530-87-2
Carcinogenicity
Administrative data
Description of key information
No data are available for carcinogenicity; however, testing is not considered necessary because:
• The substance does not have a wide-dispersive use (see Section 9 for further details);
• There is no evidence from the repeated dose studies that the substance is able to induce pre-neoplastic lesions. The key repeated dose inhalation study showed signs of minimal/mild hyperplasia in the bladder; however, these are not considered to be adverse (see discussion in Section 5.6). There is no evidence for genotoxicity of (3-chloropropyl)trimethoxysilane. Therefore, even if the hyperplastic changes are real (which is not known because it is not known whether the urinary bladder was inflated with fixative before examination), it is highly unlikely that the minimal/mild proliferative changes of the bladder are caused by a urinary bladder genotoxic carcinogen.
Key value for chemical safety assessment
Justification for classification or non-classification
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
