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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1974
Report date:
1974

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
other: substantially saturated vapor
GLP compliance:
no
Test type:
other: substantially saturated vapour
Limit test:
no

Test material

Constituent 1

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation
Vehicle:
other: unchanged (no vehicle)
Details on inhalation exposure:
Substantially saturated vapor was prepared by spreading 50 grams of chemical over 200 cm(2) area on shallow tray placed near the top of a 120-litre glass chamber which was then sealed for at least 16 hours while an intermittently operated fan agitated the internal chamber atmosphere. 
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
8 h
No. of animals per sex per dose:
6
Control animals:
not specified
Details on study design:
Rats introduced in a gasketed drawer-type cage designed and operated to minimize vapor loss. The study was conducted at 20°C. The animals were observed for 14 days postexposure for signs of toxicity.
Statistics:
Not applicable.

Results and discussion

Effect levels
Remarks on result:
other: Exposure to substantially saturated vapor for 8 hours caused no mortality.
Mortality:
Exposure to substantially saturated vapor for 8 hours caused no mortality.
Clinical signs:
other: No signs and/or symptoms were reported.
Body weight:
Weight change over the 14-day postexposure period ranged from 51 to 71 grams.  

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The findings of a 8-hr exposure to substantially saturated vapour of (3-chloropropyl)trimethoxysilane indicate a low potential for toxicity by acute inhalation exposure.