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EC number: 219-787-9 | CAS number: 2530-87-2
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- other: substantially saturated vapor
- GLP compliance:
- no
- Test type:
- other: substantially saturated vapour
- Limit test:
- no
Test material
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- Substantially saturated vapor was prepared by spreading 50 grams of chemical over 200 cm(2) area on shallow tray placed near the top of a 120-litre glass chamber which was then sealed for at least 16 hours while an intermittently operated fan agitated the internal chamber atmosphere.
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 8 h
- No. of animals per sex per dose:
- 6
- Control animals:
- not specified
- Details on study design:
- Rats introduced in a gasketed drawer-type cage designed and operated to minimize vapor loss. The study was conducted at 20°C. The animals were observed for 14 days postexposure for signs of toxicity.
- Statistics:
- Not applicable.
Results and discussion
Effect levels
- Remarks on result:
- other: Exposure to substantially saturated vapor for 8 hours caused no mortality.
- Mortality:
- Exposure to substantially saturated vapor for 8 hours caused no mortality.
- Clinical signs:
- other: No signs and/or symptoms were reported.
- Body weight:
- Weight change over the 14-day postexposure period ranged from 51 to 71 grams.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The findings of a 8-hr exposure to substantially saturated vapour of (3-chloropropyl)trimethoxysilane indicate a low potential for toxicity by acute inhalation exposure.
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