Registration Dossier
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EC number: 219-787-9 | CAS number: 2530-87-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1990
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: The study did not meet current guideline requirements because it was lacking in important criteria of today's standards and methods.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- other: in house protocol, substantially saturated vapor
- GLP compliance:
- not specified
- Test type:
- other: Substantially saturated vapour (static)
- Limit test:
- no
Test material
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- other:
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- A substantially saturated vapor atmosphere was generated statically by placing a sample of A-1430 into an exposure chamber and allowing the atmosphere to equilibrate overnight (ca. 18 hr). Animals were then placed in the chamber, maintained at an air temperature of 26 °C.
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 6 h
- Concentrations:
- Vapour was produced by enclosing ca. 100g of the test material in a sealed 100 to 151 animal chamber (under static conditions).
- No. of animals per sex per dose:
- 5/sex/dose
- Control animals:
- not specified
- Details on study design:
- To determine the potential for adverse effects by acute exposure to vapor generated at ambient temperature from A-1430, 5 male and 5 female rats were exposed for 6 hours to a substantially saturated vapor atmosphere from the material. The atmosphere was generated statically by placing a sample of A-1430 into an exposure chamber and allowing the atmosphere to equilibrate overnight (ca. 18 hr). Animals were then placed in the chamber, maintained at an air temperature of 26°C. Animals were observed for signs of toxic and/or pharmacologic effects during exposure and over a 14-day postexposure period. Survivors were sacrificed at the end of the observation period for necropsy examination.
- Statistics:
- Not applicable.
Results and discussion
- Mortality:
- No animals died during exposure or in the postexposure observation period.
- Clinical signs:
- other: Hyperactivity was seen during exposure and disappeared the day following exposure.
- Body weight:
- Animals gained weight over the two-week observation period.
- Gross pathology:
- Necropsy revealed no gross pathological features.
Any other information on results incl. tables
Hyperactivity at 30 minutes; animals periodically rubbed head, eyes and nose during exposure. Recovery at 1 day. No gross lesions.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- The findings of a 6-hr exposure to substantially saturated vapour of 3-chloropropyltrimethoxysilane indicate a low potential for toxicity by acute inhalation exposure.
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