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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1968-04-23
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Comparable to the OECD Guideline, Pre GLP study. Not a full study report.
Justification for type of information:
Please see Category Approach
Cross-referenceopen allclose all
Reason / purpose:
reference to same study
Reason / purpose:
reference to other study
Reason / purpose:
read-across source
Reference
Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1968-04-23
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Comparable to the OECD Guideline, Pre GLP study. Not a full study report.
Reason / purpose:
reference to same study
Reason / purpose:
reference to other study
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Deviations:
yes
Remarks:
6 animals were used for study instead of 10 (5 male and 5 female animals)
Principles of method if other than guideline:
None
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes
Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
TEST ANIMALS- Source: Not available- Age at study initiation: Not available- Weight at study initiation: 2703 grams (Abraded skin), 2730 grams (Intact skin)- Fasting period before study: Not available- Housing: Not available- Diet (e.g. ad libitum): Not available- Water (e.g. ad libitum): Not available- Acclimation period: Not availableENVIRONMENTAL CONDITIONS- Temperature (°C): Not available- Humidity (%): Not available- Air changes (per hr): Not available- Photoperiod (hrs dark / hrs light): Not availableIN-LIFE DATES: 1968-04-23
Type of coverage:
not specified
Vehicle:
not specified
Details on dermal exposure:
TEST SITE- Area of exposure: Not available- % coverage: Not available- Type of wrap if used: Not availableREMOVAL OF TEST SUBSTANCE- Washing (if done): Not available- Time after start of exposure: Not availableTEST MATERIAL- Amount(s) applied (volume or weight with unit): 2 ml/kg bw- Concentration (if solution): Not available- Constant volume or concentration used: yes- For solids, paste formed: Not availableVEHICLE- Amount(s) applied (volume or weight with unit): Not available- Concentration (if solution): Not available- Lot/batch no. (if required): Not available- Purity: Not available
Duration of exposure:
Not available
Doses:
2000 mg/kg bw
No. of animals per sex per dose:
Total 6 animals were taken for the study. Sex was not mentioned.
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days- Frequency of observations and weighing: Not available- Necropsy of survivors performed: Not available- Other examinations performed: Clinical signs, body weight
Statistics:
None
Preliminary study:
None
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Mortality:
0/3 (Abraded skin), 0/3 (Intact skin)
Clinical signs:
Sodium Cumene Suphonate elicited moderate primary irritation on the test sites.
Body weight:
Normal body weight gain.
Gross pathology:
Not available
Other findings:
- Organ weights: None- Histopathology: None- Potential target organs: None- Other observations: None

None

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: OECD GHS
Conclusions:
The LD50 > 2000 mg/kg bw and test substance is considered practically non toxic.
Executive summary:

The LD50 was >2000 mg/kg bw. This test substance is practically non toxic.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1968
Report Date:
1968

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Deviations:
yes
Remarks:
6 animals were used for study instead of 10 (5 male and 5 female animals)
Principles of method if other than guideline:
None
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Test material form:
solid: bulk
Details on test material:
- Name of test material : K-Cumenesulfonate (dried material)
- Substance type: Product
- Physical state: solid
- Analytical purity:
- Impurities (identity and concentrations):
- Purity test date:
- Lot/batch No.: T7714
- Expiration date of the lot/batch:

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
TEST ANIMALS- Source: Not available- Age at study initiation: Not available- Weight at study initiation: 2703 grams (Abraded skin), 2730 grams (Intact skin)- Fasting period before study: Not available- Housing: Not available- Diet (e.g. ad libitum): Not available- Water (e.g. ad libitum): Not available- Acclimation period: Not availableENVIRONMENTAL CONDITIONS- Temperature (°C): Not available- Humidity (%): Not available- Air changes (per hr): Not available- Photoperiod (hrs dark / hrs light): Not availableIN-LIFE DATES: 1968-04-23

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Details on dermal exposure:
TEST SITE- Area of exposure: Not available- % coverage: Not available- Type of wrap if used: Not availableREMOVAL OF TEST SUBSTANCE- Washing (if done): Not available- Time after start of exposure: Not availableTEST MATERIAL- Amount(s) applied (volume or weight with unit): 2 ml/kg bw- Concentration (if solution): Not available- Constant volume or concentration used: yes- For solids, paste formed: Not availableVEHICLE- Amount(s) applied (volume or weight with unit): Not available- Concentration (if solution): Not available- Lot/batch no. (if required): Not available- Purity: Not available
Duration of exposure:
Not available
Doses:
2000 mg/kg bw
No. of animals per sex per dose:
Total 6 animals were taken for the study. Sex was not mentioned.
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days- Frequency of observations and weighing: Not available- Necropsy of survivors performed: Not available- Other examinations performed: Clinical signs, body weight
Statistics:
None

Results and discussion

Preliminary study:
None
Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Mortality:
0/3 (Abraded skin), 0/3 (Intact skin)
Clinical signs:
Sodium Cumene Suphonate elicited moderate primary irritation on the test sites.
Body weight:
Normal body weight gain.
Gross pathology:
Not available
Other findings:
- Organ weights: None- Histopathology: None- Potential target organs: None- Other observations: None

Any other information on results incl. tables

None

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: OECD GHS
Conclusions:
The LD50 > 2000 mg/kg bw and test substance is considered practically non toxic.
Executive summary:

The LD50 was >2000 mg/kg bw. This test substance is practically non toxic.