Registration Dossier
Registration Dossier
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EC number: 629-764-9 | CAS number: 164524-02-1
Endpoint summary
Administrative data
Description of key information
Additional information
The HYDROTOPES Category comprises the following 6 substances:
STS - Sodium toluene 4-sulphonate (CAS 657-84-1, EC 211-522-5)
SXS - Sodium (xylenes and 4-ethylbenzene) sulphonate (EC 701-037-1)
NH4XS - Ammonium (xylenes and 4-ethylbenzene) sulphonate (EC 943-024-5)
SCS - Sodium p-cumenesulphonate (CAS 15763-76-5, EC 239-854-6)
KCS - Potassium p-cumenesulphonate (CAS 164524-02-1, EC 629-764-9)
NH4CS - Ammonium p-cumenesulphonate (CAS 680972-33-2, EC 811-484-5)
In addition CaXS (Calcium Xylenesulphonate, CAS 28088-63-3, EC 248-829-9) was evaluated for complete the assessment despite it is not registered under REACH.
From the available short-term toxicity results it can be concluded that aquatic organisms are of low sensitivity to Hydrotrope category substances. Most studies across the three trophic levels report no toxicity at the highest concentration tested. The studies relating to microbial activity (respiration) indicate low potential for toxicity at similar concentrations to fish, invertebrates and algae. The experimental available data on substances are consistent and confirms low eco-toxicity of the Hydrotropes to aquatic organisms including fish, invertebrates, algae and microorganisms. The density of the aquatic short term toxicity data is high enough to consider the hydrotropes as a category and the available information support a regular pattern of same absence of and type of effects with regard to aquatic toxicity.
The available studies on aquatic toxicity are:
Short term toxicity to fish
SXS (1993, no GLP): LC50 > 1000 mg/l (a.i.)
CaXS (1994, GLP): LC50 > 1580 mg/l (a.i.)
SCS (2020, GLP): LC50 > 100 mg/l (a.i.)
TSA (1981, no GLP): LC50 > 325 mg/l (a.i.)
Short term toxicity to aquatic invertebrates
STS (2020, GLP): EC50 = 217 mg/l (a.i.)
STS (1995, GLP): EC50 = 54 mg/l (disregarded)
SXS (1993, no GLP): EC50 > 1000 mg/l
SXS (1995, GLP not specified): EC50 > 40.3 mg/l (a.i.) Limit test, highest concentration tested
CaXS (1994, GLP): EC50 > 1020 mg/l (a.i.)
SCS (1995, GLP not specified): EC50 > 40.3 (a.i.)
SCS (2020, GLP): EC50 > 121 mg/l (a.i.)
Toxicity to aquatic plants (algae)
STS (1995, GLP): EC50 72 h = 150 mg/l (a.i.)
SXS (1993, no GLP): EC50 96 h > 230 mg/l (a.i.)
CaXS (1994, GLP): EC50 96 h = 758 mg/l (a.i.)
SCS (2020, GLP): EC50 72 h > 100 mg/l (a.i.)
Toxicity to micro-organism
STS (2009, GLP): EC10 3 h > 1000 mg/l (a.i.)
SCS (2009, GLP): EC10 3 h > 1000 mg/l (a.i.)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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