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EC number: 200-338-0
CAS number: 57-55-6
There are several guideline studies
available for freshwater fish. The studies are all static and the test
concentrations are measured in most of the studies. The
lowest observed effect concentration is a 96 -h LC50 value of 40613 mg/l
in a study with Oncorhynchus mykiss (Beak
Consultants Limited, 1995).
There are several guideline studies
available for freshwater invertebrates. The most critical study for is
therefore chosen as the key study. For freshwater invertebrates the
lowest observed effect concentration is a 48-h LC50 value of 18340 mg/l
in Ceriodaphnia dubia (Pillard, 1995). In marine water, the lowest 96-h
LC50 is 18800 mg/l in Mysidopsis bahia (new name: Americamysis
bahia) (ARCO Chemical Company, 1990). Both values will be used in
One chronic guideline test is available
with the freshwater invertebrate Ceriodaphnia. The 7-d NOEC is
13020 mg/l (measured concentration) (Pillard, 1995).
This value will be used in the
Experimental data are available with
fresh water and marine algae. In fresh water, the 96-h EC50 is 19,000
mg/l inPseudokirchnerella subcapitata (reported as Selenastrum
capricornutum) and the 14 -d NOEC is 15,000 mg/l (ARCO Chemical
Company, 1990). In marine water, the 96-h EC50 is 19,100 mg/l in Skeletonema
costatum. These values will be used in the assessment.
Reliable test data are available for
toxicity to microorganisms. In a near guideline test with Pseudomonas
putidaan 18-h NOEC of >20,000 mg/l was determined in a growth
inhibition test. Nominal values were reported (The Dow Chemical Company,
1992). This value will be used in the assessment.
A GLP compliant guideline study is
available for the sediment compartment. The 10-d LC50 is 6983 mg/kg to
the marine amphipod Corophium volutator (Halliburton Energy
Services, 2004). As only long-term testing can be used in the hazard
assessment according to the REACH.
According to Directive 67/548/EEC, results of validated structure
activity relationships and expert judgment may also be taken into
account where appropriate with regard to classification and labelling of
Three short-term L(E)C50 of each trophic levels (fish, invertebrates and
algae) and two long-term NOEC from two trophic levels (invertebrates and
algae) are available. The lowest no effect concentration is the 7-d NOEC
of 13,020 mg/l for the freshwater invertebrate Ceriodaphnia).
Based on the result of the octanol/water partition coefficient (Log Kow
= - 1.07), monopropylene glycol is not expected to significantly
accumulate in aquatic organisms. Furthermore, the substance is found to
be readily biodegradable. For these reasons, monopropylene glycol is not
classified in Annex I of Directive 67/548/EEC and according to the EU
Classification, Labelling and Packaging of Substances and Mixtures (CLP)
Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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