Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin sensitisation

Currently viewing:

Administrative data

Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: secondary literature

Data source

Reference
Reference Type:
secondary source
Title:
No information
Author:
Magnusson, B. and Kligman, A.M.
Year:
1969
Bibliographic source:
J. Invest.Dermatol. 52, 268-276, cited in: Gad, S.C. et al.: Toxicol. Appl.Pharmacol. 84, 93-114 (1986) and Vial, T. and Descotes, J.: Toxicology 93, 63-75 (1995)

Materials and methods

Principles of method if other than guideline:
according to Magnusson and Kligman
GLP compliance:
no
Type of study:
guinea pig maximisation test

Test material

Constituent 1
Chemical structure
Reference substance name:
Aluminium chloride
EC Number:
231-208-1
EC Name:
Aluminium chloride
Cas Number:
7446-70-0
Molecular formula:
AlCl3
IUPAC Name:
trichloroalumane
Details on test material:
no data on purity of the compound

In vivo test system

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified

Study design: in vivo (non-LLNA)

Inductionopen allclose all
Route:
intradermal
Vehicle:
petrolatum
Concentration / amount:
intradermal induction: 2%
topical induction: 25%
challenge: 2%
Challenge
Concentration / amount:
intradermal induction: 2%
topical induction: 25%
challenge: 2%
No. of animals per dose:
no data

Results and discussion

Applicant's summary and conclusion

Interpretation of results:
not sensitising
Remarks:
Migrated information